为了探究高分辨率集成动态校正回顾型成像(iEPI)在直肠癌中的可行性，本研究共招募了78名非黏液性直肠腺癌患者。使用原型高分辨率iEPI序列、高分辨率单次拍摄EPI(sEPI)序列和sEPI序列，进行主观和客观评估和明显扩散系数(ADC)值的测量和比较。斯皮尔曼等级相关性分析和接收操作特征曲线进行了评估，以评估肿瘤ADC值、相应的T期和直肠癌分化程度之间的相关性。两位读者都认为高分辨率iEPI的图像质量(IQ)优于高分辨率sEPI和sEPI (p<0.001)。高分辨率iEPI的信噪比、对比度和信号强度比均显著高于另外两个序列(p<0.001)。在低到高分化的直肠癌组中，三个EPI序列的肿瘤ADC值没有显著差异。在三个DWI序列上，ADC值与直肠癌病理T期之间呈负相关(r=-0.693，-0.689，-0.640，p<0.001)。高分辨率iEPI、高分辨率sEPI和sEPI在预测分化良好的直肠癌的AUC值分别为0.910、0.761和0.725。总之，相对于另外两个序列，高分辨率iEPI提供了显著更高的IQ和稳定的ADC。在三个检测序列中，高分辨率iEPI对具有不同分化程度的直肠癌的鉴别诊断效果最优。•当评估直肠癌时，高分辨率iEPI提供了明显更好的IQ。•三个EPI序列中，高分辨率sEPI的AUC值在预测分化良好的直肠癌中最高。 ©2023.作者（们），在欧洲放射学会的独家许可下。

To investigate the feasibility of high-resolution integrated dynamic shimming echo planar imaging (iEPI) applied to rectal cancer.A total of seventy-eight patients with non-mucinous rectum adenocarcinoma were enrolled in this study. Using a prototype high-resolution iEPI sequence, high-resolution single-shot EPI (sEPI) sequence, and sEPI sequence, subjective and objective assessment and apparent diffusion coefficient (ADC) value were measured for comparison. The spearman rank correlation analysis test and the receiver operating characteristic curve were performed to evaluate correlation between tumor ADC values, corresponding T stage, and differentiation degree of rectal cancer.The subjective assessment of the image quality (IQ) of high-resolution iEPI was rated superior to high-resolution sEPI and sEPI by both readers (p < 0.001). Signal-to-noise ratio, contrast-to-noise, and signal-intensity ratio were significantly higher in high-resolution iEPI than the other two sequences (p < 0.001). There was no significant difference of tumor ADC values among three EPI sequences in the group of low- to well-differentiated rectal cancer. An inverse correlation was noted between ADC values on three DWI sequences and pathological T stage of rectal cancer (r =  - 0.693, - 0.689, - 0.640, p < 0.001). The AUC values of high-resolution iEPI, high-resolution sEPI, and sEPI in predicting well-differentiated rectal cancer were 0.910, 0.761, and 0.725 respectively.In conclusion, the high-resolution iEPI provided significantly higher IQ and stable ADC compared to another two sequences. High-resolution iEPI has the highest efficacy among three examined sequences in differentiation of rectal cancer with different degrees of differentiation.• High-resolution iEPI provided a significantly better IQ than high-resolution sEPI and sEPI when assessing rectal cancer. • The AUC of high-resolution sEPI was the highest among three EPI sequences in predicting well-differentiated rectal cancer.© 2023. The Author(s), under exclusive licence to European Society of Radiology.