基于聚乳酸（PLA）和纳米羟基磷灰石（nano-HAP）的新型生物材料通过电纺技术获得，并经过多西环素（多西）负载，其免疫调节效应在动物模型中进行了评估。在Wistar大鼠的下门牙上使用缚带技术诱发局部牙周炎，研究其作为局部非手术治疗牙周炎的治疗能力。在诱发疾病后，结合新材料的应用，施用了非手术治疗的牙齿清洁与根面平整术。临床上，采用牙齿松动度和龈炎指数得分以及组织学评估来评估治疗效果。同时监测唾液中基质金属蛋白酶8（MMP-8）和血浆中白细胞介素1（IL-1）、白细胞介素6（IL-6）和肿瘤坏死因子α（TNF-α）的浓度。在缚带应用后的两周内，成功诱发了大鼠的牙周疾病。与简单的牙齿清洁和根面平整术相比，通过电纺技术获得的新型生物材料在改善临床参数方面更为有效，同时降低了唾液中的MMP-8和血浆中的IL-1和TNF-α浓度。因此，新型电纺生物材料可以成为非手术牙周治疗的有力辅助手段。

The immunomodulatory effect of a novel biomaterial obtained through electrospinning, based on polylactic acid (PLA) and nano-hydroxyapatite (nano-HAP), loaded with doxycycline (doxy) was evaluated in an animal model. The treatment capabilities as a local non-surgical treatment of periodontitis was investigated on the lower incisors of Wistar rats, after the induction of localized periodontitis using the ligature technique. Following the induction of the disease, the non-surgical treatment of scaling and root planing was applied, in conjunction with the application of the new material. The results of the treatment were evaluated clinically, using the tooth mobility and gingival index scores, as well as histologically. The salivary concentrations of matrix metalloproteinase 8 (MMP-8) and plasmatic concentrations of interleukin 1 (IL-1), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) were also monitored. Two weeks after the ligature application, the periodontal disease was successfully induced in rats. The application of the novel biomaterial obtained through electrospinning was proven to be more effective in improving the clinical parameters, while decreasing the salivary MMP-8 and plasmatic IL-1 and TNF-α concentrations, compared to the simple scaling and root planing. Thus, the novel electrospun biomaterial could be a strong candidate as an adjuvant to the non-surgical periodontal therapy.