转移预防：如何捕捉转移种子。
Metastasis prevention: How to catch metastatic seeds.
发表日期：2023 Feb 24
作者：
Tatiana S Gerashchenko, Anastasia A Schegoleva, Anna A Khozyainova, Evgeny L Choinzonov, Evgeny V Denisov
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
摘要：
尽管抗癌治疗方面已经取得了相当大的进展，但转移仍然是癌症死亡的主要原因。因此，当前癌症治疗策略应该转向预防转移。针对转移途径进行定位治疗是一种有前途的治疗机会，旨在阻碍肿瘤细胞的传播和转移殖民。在本综述中，我们重点关注过去五年展示出通过针对淋巴结转移、肿瘤细胞渗出、活性氧、前转移灶、外泌体机制和休眠来抑制转移的临床前研究和临床试验。版权所有 © 2023 Elsevier B.V. 发布。
Despite considerable advances in the evolution of anticancer therapies, metastasis still remains the main cause of cancer mortality. Therefore, current strategies for cancer cure should be redirected towards prevention of metastasis. Targeting metastatic pathways represents a promising therapeutic opportunity aimed at obstructing tumor cell dissemination and metastatic colonization. In this review, we focus on preclinical studies and clinical trials over the last five years that showed high efficacy in suppressing metastasis through targeting lymph node dissemination, tumor cell extravasation, reactive oxygen species, pre-metastatic niche, exosome machinery, and dormancy.Copyright © 2023. Published by Elsevier B.V.