代谢适应是肿瘤的新兴标志。新生脂肪酸合成是一种重要的代谢过程，可以产生代谢中间产物，用于能量储存、膜脂质生物合成和信号分子的产生。乙酰辅酶A羧化酶1（ACC1）是脂肪酸合成中的关键酶，它可以羧化乙酰辅酶A来形成丙酰辅酶A。乙酰辅酶A羧化酶1在脂肪酸合成中的作用使其成为治疗非酒精性脂肪肝病、肥胖和糖尿病等多种代谢疾病的有前途的治疗靶点。肿瘤拥有高能量流和对脂肪酸合成的强烈依赖性。因此，乙酰辅酶A羧化酶抑制剂已成为抗肿瘤治疗的潜在选择。在本综述中，我们首先介绍了乙酰辅酶A羧化酶1的结构和表达模式。我们还讨论了乙酰辅酶A羧化酶1在各种癌症类型的发生和发展中的分子机制。此外，我们还讨论了乙酰辅酶A羧化酶1抑制剂。总之，我们总结了乙酰辅酶A羧化酶1和肿瘤发生发展之间的相互作用，表明乙酰辅酶A羧化酶1是治疗肿瘤的有前途的治疗靶点。Copyright © 2023 Yu, Nie, Wang, Di, Chen and Ren.

Metabolic adaptation is an emerging hallmark of tumors. De novo fatty acid synthesis is an important metabolic process to produce metabolic intermediates for energy storage, biosynthesis of membrane lipids and generation of signaling molecules. Acetyl-CoA carboxylase 1 (ACC1) is a critical enzyme in the fatty acid synthesis, which carboxylates acetyl-CoA carboxylic acid to form malonyl-CoA. The role of acetyl-CoA carboxylase 1 in fatty acid synthesis makes it a promising therapeutic target for various metabolic diseases such as non-alcoholic fatty liver disease, obesity and diabetes. Tumors have a high energy flow and a strong dependence on fatty acid synthesis. Thus, acetyl-CoA carboxylase inhibition has become a potential choice for anti-tumor therapy. In this review, we first introduced the structure and expression pattern of Acetyl-CoA carboxylase 1. We also discussed the molecular mechanisms of acetyl-CoA carboxylase 1 in the initiation and progression of various cancer types. Furthermore, acetyl-CoA carboxylase1 inhibitors has also been discussed. Collectively, we summarized the interplay between acetyl-CoA carboxylase 1 and tumorigenesis, indicating acetyl-CoA carboxylase 1 as a promising therapeutic target for tumor management.Copyright © 2023 Yu, Nie, Wang, Di, Chen and Ren.