研究动态
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描绘EYA4在调节肿瘤中的作用。

Delineating the tumour-regulatory roles of EYA4.

发表日期:2023 Feb 25
作者: Zhi Xiong Chong, Wan Yong Ho, Swee Keong Yeap
来源: BIOCHEMICAL PHARMACOLOGY

摘要:

Eyes absent homolog 4 (EYA4)是一种蛋白质,调节许多重要的细胞过程和器官成形途径。它具有磷酸酶、水解酶和转录激活功能。Eya4基因的突变可导致感音神经性听力损失和心脏疾病。在大多数非神经系统癌症,如胃肠道(GIT)、血液和呼吸系统的癌症中,EYA4作为潜在的抑癌基因发挥作用。然而,在神经系统肿瘤,如胶质瘤、星形细胞瘤和恶性周围神经鞘瘤(MPNST)中,它则发挥促癌作用。EYA4与PI3K/AKT、JNK/cJUN、Wnt/GSK-3β和细胞周期途径的各种信号蛋白相互作用,以发挥促癌或抑癌作用。Eya4的组织表达水平和甲基化谱可帮助预测癌症患者的预后和抗癌治疗反应。定向和改变Eya4的表达和活性可能是一种潜在的抑癌治疗策略。总之,EYA4在不同的人类癌症中可能具有潜在的促癌和抑癌作用,并有可能成为各种癌症类型的预测生物标志物和治疗药物。 版权所有 ©2023 Elsevier Inc. 保留所有权利。
Eyes absent homolog 4 (EYA4) is a protein that regulates many vital cellular processes and organogenesis pathways. It possesses phosphatase, hydrolase, and transcriptional activation functions. Mutations in the Eya4 gene can cause sensorineural hearing loss and heart disease. In most non-nervous system cancers such as those of the gastrointestinal tract (GIT), hematological and respiratory systems, EYA4 acts as a putative tumor suppressor. However, in nervous system tumors such as glioma, astrocytoma, and malignant peripheral nerve sheath tumor (MPNST), it plays a putative tumor-promoting role. EYA4 interacts with various signaling proteins of the PI3K/AKT, JNK/cJUN, Wnt/GSK-3β, and cell cycle pathways to exert its tumor-promoting or tumor-suppressing effect. The tissue expression level and methylation profiles of Eya4 can help predict the prognosis and anti-cancer treatment response among cancer patients. Targeting and altering Eya4 expression and activity could be a potential therapeutic strategy to suppress carcinogenesis. In conclusion, EYA4 may have both putative tumor-promoting and tumor-suppressing roles in different human cancers and has the potential to serve as a prognostic biomarker and therapeutic agent in various cancer types.Copyright © 2023. Published by Elsevier Inc.