在过去的十年中，长非蛋白编码RNA（lncRNA）在p53介导的肿瘤抑制中的作用越来越受到重视。因此，识别p53调控的lncRNA可以作为选定和优先进行功能分析的有前途的起点。通过整合转录组和转录因子结合数据，我们识别出379个经常被p53不同调控的lncRNA。通过分析p53调控它们的机制，我们识别出一组通过p53-RFX7和p53-p21-DREAM/RB:E2F途径直接或间接调控的lncRNA集合。重要的是，我们发现多个p53响应的lncRNA和它们的蛋白编码宿主基因是共同调控的，揭示了p53可能调控lncRNA的重要机制。对转录组数据和癌症患者的临床数据的进一步分析表明，经常被p53调控的lncRNA与患者的生存率相关。综合分析p53调控的lncRNA的景观提供了一个强大的资源，有助于确定lncRNA的功能，并显示了可用于开发抗癌方法的p53依赖性调控的机制。本文受版权保护，版权所有。

The role of long non-protein-coding RNAs (lncRNAs) in p53-mediated tumor suppression has become increasingly appreciated in the past decade. Thus, the identification of p53-regulated lncRNAs can be a promising starting point to select and prioritize lncRNAs for functional analyses. By integrating transcriptome and transcription factor binding data, we identified 379 lncRNAs that are recurrently differentially regulated by p53. Dissecting the mechanisms by which p53 regulates many of them, we identified sets of lncRNAs regulated either directly by p53 or indirectly through the p53-RFX7 and p53-p21-DREAM/RB:E2F pathways. Importantly, we identified multiple p53-responsive lncRNAs that are co-regulated with their protein-coding host genes, revealing an important mechanism by which p53 may regulate lncRNAs. Further analysis of transcriptome data and clinical data from cancer patients showed that recurrently p53-regulated lncRNAs are associated with patient survival. Together, the integrative analysis of the landscape of p53-regulated lncRNAs provides a powerful resource facilitating the identification of lncRNA function and displays the mechanisms of p53-dependent regulation that could be exploited for developing anti-cancer approaches.This article is protected by copyright. All rights reserved.