N6-甲基腺苷（m6A）甲基化是真核生物mRNA中最普遍的内部修饰。通过m6A写入者、擦除者和读取者的复杂功能，m6A修饰参与了数种生理和病理过程。大量研究表明在各种肿瘤中存在m6A修饰，并影响肿瘤的发生、转移和耐药性。最近的证据还揭示了m6A修饰在肿瘤免疫调节中的新兴作用，肿瘤微环境中也显示出不同的m6A甲基化模式。为了描述m6A甲基化在肿瘤免疫微环境中的调节作用及其对免疫逃避的影响，本综述聚焦于免疫微环境，该环境具有低氧、代谢重编程、酸性和免疫抑制等特点，并概述不同刺激下的m6A调控免疫微环境和免疫逃避机制。此外，还总结了抗肿瘤免疫细胞中的m6A调控模式。© 2023作者。

N6-methyladenosine (m6A) methylation is the most universal internal modification in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and readers, m6A modulation is involved in myriad physiological and pathological processes. Extensive studies have demonstrated m6A modulation in diverse tumours, with effects on tumorigenesis, metastasis, and resistance. Recent evidence has revealed an emerging role of m6A modulation in tumour immunoregulation, and divergent m6A methylation patterns have been revealed in the tumour microenvironment. To depict the regulatory role of m6A methylation in the tumour immune microenvironment (TIME) and its effect on immune evasion, this review focuses on the TIME, which is characterized by hypoxia, metabolic reprogramming, acidity, and immunosuppression, and outlines the m6A-regulated TIME and immune evasion under divergent stimuli. Furthermore, m6A modulation patterns in anti-tumour immune cells are summarized.© 2023. The Author(s).