肿瘤微环境是一个复杂的生态系统，推动着癌症的进展并抑制着免疫力。虽然免疫检查点抑制剂在部分患者中表现出强大的潜力，但对抑制机制的更好理解可能会激发提高免疫治疗效果的方法。本期《癌症研究》中的一项新研究集中于针对前期胃癌模型中的癌相关成纤维细胞，旨在重新平衡抗癌免疫力并加强治疗对检查点阻滞抗体的反应，同时也探讨了多靶向酪氨酸激酶抑制剂在胃肠道癌症治疗中的潜力。请参阅Akiyama等人的相关文章，第753页。©2023美国癌症研究协会。

The tumor microenvironment is a complex ecosystem that drives cancer progression and restrains immunity. Although immune checkpoint inhibitors have shown strong potential in a subset of patients, a better understanding of suppressive mechanisms may inspire ways to improve immunotherapeutic efficacy. A new study in this issue of Cancer Research focuses on targeting cancer-associated fibroblasts in preclinical models of gastric tumors. Aiming to rebalance anticancer immunity and enhance treatment responses to checkpoint-blocking antibodies, this work also addresses the potential for multitarget tyrosine kinase inhibitors in treating gastrointestinal cancer. See related article by Akiyama et al., p. 753.©2023 American Association for Cancer Research.