白血病药物抗性中的非编码RNA: 分子机制与信号通路的新视角。
Non-coding RNAs in leukemia drug resistance: new perspectives on molecular mechanisms and signaling pathways.
发表日期：2023 Aug 01
作者：
Atefe Rahmati, Alireza Mafi, Omid Vakili, Firooze Soleymani, Zahra Alishahi, Sheida Yahyazadeh, Yasaman Gholinezhad, Malihe Rezaee, Thomas P Johnston, Amirhossein Sahebkar
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS
摘要：
正如几乎所有癌症类型一样，白血病需要及时诊断才能有效治愈。药物外流、减弱药物摄取、改变药物代谢以及表观遗传改变是导致药物耐药性发展的关键机制之一。所有这些机制都由上调和下调因子协调，其中非编码RNAs（ncRNAs）大多数情况下不编码特定蛋白质；尽管如此，其中一些被发现具有编码蛋白质的潜力。尽管如此，ncRNAs主要以调节生理过程以及与之相关的病理过程（如细胞增殖、凋亡和免疫反应）而闻名。具体而言，在白血病化疗耐药的情况下，已经认识到ncRNAs在调控耐药性的发生和发展中起着关键作用。在这里，我们对ncRNAs在白血病耐药性发展中对分子机制和信号通路的影响进行了全面回顾。© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Like almost all cancer types, timely diagnosis is needed for leukemias to be effectively cured. Drug efflux, attenuated drug uptake, altered drug metabolism, and epigenetic alterations are just several of the key mechanisms by which drug resistance develops. All of these mechanisms are orchestrated by up- and downregulators, in which non-coding RNAs (ncRNAs) do not encode specific proteins in most cases; albeit, some of them have been found to exhibit the potential for protein-coding. Notwithstanding, ncRNAs are chiefly known for their contribution to the regulation of physiological processes, as well as the pathological ones, such as cell proliferation, apoptosis, and immune responses. Specifically, in the case of leukemia chemo-resistance, ncRNAs have been recognized to be responsible for modulating the initiation and progression of drug resistance. Herein, we comprehensively reviewed the role of ncRNAs, specifically its effect on molecular mechanisms and signaling pathways, in the development of leukemia drug resistance.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.