血液造血干细胞移植后内皮细胞疾病的诊断与管理。
Diagnosis and management of endothelial disorders following haematopoietic stem cell transplantation.
发表日期：2023 Aug 01
作者：
Ashley McEwan, Matthew Greenwood, Christopher Ward, David Ritchie, Jeff Szer, Elizabeth Gardiner, Andriana Colic, Julija Sipavicius, Yvonne Panek-Hudson, Ian Kerridge
来源：
Stem Cell Research & Therapy
摘要：
造血干细胞移植是治疗多种恶性和非恶性疾病的主要疗法。患者和移植特定因素驱动了造血干细胞移植后的内皮活化和功能障碍。这可能表现为相对罕见的内皮损伤综合征之一，如窦样阻塞综合征，移植相关性血栓性微血管病、特发性肺炎综合征、毛细血管渗漏综合征、植入综合征或后颈可逆性脑病综合征。本综述关注这些疾病的发病机制、分类和诊断，并提供风险缓解和治疗的指导。© 2023The Authors. 由澳大利亚约翰·威立出版公司代表澳大利亚和新西兰医学学院出版的《内科杂志》。
Haematopoietic stem cell transplantation is a mainstay of therapy for numerous malignant and nonmalignant diseases. Endothelial activation and dysfunction occur after stem cell transplantation, driven by various patient- and transplant-specific factors. This can manifest as one of the relatively uncommon endothelial injury syndromes, such as sinusoidal obstruction syndrome, transplant-associated thrombotic microangiopathy, idiopathic pneumonia syndrome, capillary leak syndrome, engraftment syndrome or posterior reversible encephalopathy syndrome. This review focuses on the pathogenesis, classification and diagnosis of these disorders, as well as provides guidance on risk mitigation and treatment.© 2023 The Authors. Internal Medicine Journal published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Physicians.