胰腺癌的三级淋巴结构：免疫疗法的新靶点。
Tertiary lymphoid structures in pancreatic cancer: a new target for immunotherapy.
发表日期：2023
作者：
Xinlei Zou, Canghai Guan, Jianjun Gao, Wujiang Shi, Yunfu Cui, Xiangyu Zhong
来源：
Frontiers in Immunology
摘要：
胰腺癌（PC）具有极强的恶性并对现有免疫疗法的反应有限，这是由于其肿瘤微环境（TME）缺氧和免疫抑制的特性所致。免疫细胞（B细胞、T细胞、树突状细胞等）的聚集是在各种慢性炎症情况下诱导的，如感染、炎症和肿瘤，称为第三淋巴结构（TLS）。多项研究已经显示，在PC的肿瘤内和周围组织中都可以找到TLS。尽管在肿瘤内TLS被认为在多种肿瘤中发挥积极作用，包括PC，但在周围组织中TLS的作用仍不清楚。PC中肿瘤内TLS的形成与良好的预后相关。此外，TLS可以用作评估治疗效果的指标。有针对性地诱导TLS的形成可能成为PC的新免疫治疗途径。本综述总结了胰腺TME中TLS的形成、特征、相关临床结果和临床应用。我们旨在为PC的未来免疫治疗提供新思路。版权所有 © 2023年邹、关、高、石、崔和钟。
Pancreatic cancer (PC) is extremely malignant and shows limited response to available immunotherapies due to the hypoxic and immunosuppressive nature of its tumor microenvironment (TME). The aggregation of immune cells (B cells, T cells, dendritic cells, etc.), which is induced in various chronic inflammatory settings such as infection, inflammation, and tumors, is known as the tertiary lymphoid structure (TLS). Several studies have shown that TLSs can be found in both intra- and peritumor tissues of PC. The role of TLSs in peritumor tissues in tumors remains unclear, though intratumoral TLSs are known to play an active role in a variety of tumors, including PC. The formation of intratumoral TLSs in PC is associated with a good prognosis. In addition, TLSs can be used as an indicator to assess the effectiveness of treatment. Targeted induction of TLS formation may become a new avenue of immunotherapy for PC. This review summarizes the formation, characteristics, relevant clinical outcomes, and clinical applications of TLSs in the pancreatic TME. We aim to provide new ideas for future immunotherapy of PC.Copyright © 2023 Zou, Guan, Gao, Shi, Cui and Zhong.