研究动态
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输注血小板进行抗凝治疗严重血小板减少的急性肢体缺血。

Anticoagulation With Platelet Transfusions for Acute Limb Ischemia With Severe Thrombocytopenia.

发表日期:2023 Jul
作者: Khalid Shakfeh, Damian A Laber
来源: Protein & Cell

摘要:

急性肢体缺血(ALI)是一种医学和外科急症,治疗的主要手段是治疗性抗凝和手术。这些干预需要足够的血小板计数和功能。在血小板减少的患者中,抗凝和手术可能会复杂化,并且需要跨学科管理以获得最佳效果,因为文献对这一人群的资料有限。我们报告了一个严重血小板减少患者的病例,该患者由于癌相关性血栓形成(CAT)而发展为肢体缺血。我们提出了一种抗凝和围手术期血小板输注的治疗策略,成功实现了再灌流,且没有出现不良出血事件。虽然取得了成功,但需要更多数据来研究长期结果。版权所有 © 2023, Shakfeh et al.
Acute limb ischemia (ALI) is a medical and surgical emergency, and the mainstays of treatment are therapeutic anticoagulation and surgery. These interventions require adequate platelet count and functionality. Anticoagulation and surgery can be complicated in thrombocytopenic patients and require interdisciplinary management for optimal outcomes, as literature is limited in this population. We present a case of a patient with severe thrombocytopenia who developed limb ischemia from cancer-associated thrombosis (CAT). We propose a management strategy for anticoagulation and perioperative platelet transfusion, with successful revascularization without adverse bleeding events. While successful, more data is required to investigate long-term outcomes.Copyright © 2023, Shakfeh et al.