人乳头瘤病毒疫苗接种年龄对其有效性的影响：一项系统综述。
Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review.
发表日期：2023 Aug 01
作者：
Mallory K Ellingson, Hassan Sheikha, Kate Nyhan, Carlos R Oliveira, Linda M Niccolai
来源：
Immunity & Ageing
摘要：
人类乳头瘤病毒（HPV）疫苗的作用是在自然暴露之前预防感染。因此，在较年轻的年龄阶段可能更有效，因此理解在较年长的年龄接种时其有效性可能如何减弱十分重要。我们对2007年至2022年间发表的HPV疫苗有效性研究进行了系统综述，其中包括对接种初始或接种完成年龄的失败类型HPV感染、肛门生殖器疣、宫颈异常和宫颈癌有效性进行分析。在多个数据库中检索，共包含了21项研究，结果以描述性总结的形式呈现。其中17项研究发现，最年轻的年龄组中疫苗的有效性最高。较年轻的青少年（9-14岁）的疫苗有效性估计值范围为74%至93%，而15-18岁的青少年的估计值范围为12%至90%。这些结果表明，给予较年轻时的HPV疫苗对于预防HPV相关疾病结果最为有效，强调及时接种疫苗的重要性。
Human papillomavirus (HPV) vaccines work by preventing infections prior to natural exposure. Thus, it is likely more effective at younger ages, and it is important to understand how effectiveness might be diminished when administered at older ages. We conducted a systematic review of HPV vaccine effectiveness studies published between 2007 and 2022 that included an analysis of effectiveness against vaccine-type HPV infections, anogenital warts, cervical abnormalities and cervical cancer by age at vaccine initiation or completion. Searching multiple databases, 21 studies were included and results were summarized descriptively. Seventeen studies found the highest vaccine effectiveness in the youngest age group. Vaccine effectiveness estimates for younger adolescents ages 9-14 years ranged from approximately 74% to 93% and from 12% to 90% for adolescents ages 15-18 years. These results demonstrate that the HPV vaccine is most effective against HPV-related disease outcomes when given at younger ages, emphasizing the importance of on-time vaccination.