炎症是一种重要的免疫反应，有助于抵抗感染和修复组织。然而，慢性炎症与多种疾病有关，包括癌症、自身免疫性疾病、心血管疾病和神经系统疾病。这增加了人们对寻找能够调节免疫系统炎症信号通路以预防或治疗这些疾病的天然物质的兴趣。芹菜素是一种存在于许多水果、蔬菜和草药中的类黄酮。研究表明，它通过改变免疫细胞的信号通路具有抗炎作用。本综述文章讨论了关于芹菜素作为自然免疫调节剂对炎症信号机制的当前研究，例如它对核因子-kappa B、丝裂原活化蛋白激酶、雅努斯激酶/信号转导子激活因子和炎症小体信号通路的影响。还讨论了芹菜素的安全性以及它在与炎症相关的疾病中的潜在治疗用途。总的来说，数据表明芹菜素具有作为自然免疫系统炎症信号通路调节剂的引人注目的潜力。需要更多的研究来全面了解其作用机制和可能的治疗应用。© 2023 Wiley Periodicals LLC.

Inflammation is an essential immune response that helps fight infections and heal tissues. However, chronic inflammation has been linked to several diseases, including cancer, autoimmune disorders, cardiovascular diseases, and neurological disorders. This has increased interest in finding natural substances that can modulate the immune system inflammatory signaling pathways to prevent or treat these diseases. Luteolin is a flavonoid found in many fruits, vegetables, and herbs. It has been shown to have anti-inflammatory effects by altering signaling pathways in immune cells. This review article discusses the current research on luteolin's role as a natural immune system modulator of inflammatory signaling mechanisms, such as its effects on nuclear factor-kappa B, mitogen-activated protein kinases, Janus kinase/signal transducer and activator of transcription, and inflammasome signaling processes. The safety profile of luteolin and its potential therapeutic uses in conditions linked to inflammation are also discussed. Overall, the data point to Luteolin's intriguing potential as a natural regulator of immune system inflammatory signaling processes. More research is needed to fully understand its mechanisms of action and possible therapeutic applications.© 2023 Wiley Periodicals LLC.