子宫内膜异位症是一种慢性妇科疾病，其中疼痛是最常见和最致残的症状。与其他疼痛形式一样，人们越来越认识到心理过程在疼痛和疼痛影响之间的桥梁作用，然而这些过程在子宫内膜异位症中尚不为人们所了解。本研究的目的是调查对子宫内膜异位症相关的进展恐惧、意象以及解释偏差的相关性，以及它们对疼痛干扰的贡献。我们从澳大利亚子宫内膜异位症协会招募了221名参与者（平均年龄38岁，标准差为7.8）。这个横断面研究包括相关的人口统计学和子宫内膜异位症特征；用于衡量进展恐惧、意象、解释偏差和疼痛的问卷；以及用于衡量解释偏差的词汇联想任务。参与者在《进展恐惧问卷》上报告了较高的分数（平均得分为38/60），高于癌症中的得分。在控制年龄和疼痛强度的情况下，我们发现意象、解释偏差及其相互作用与进展恐惧的增加有关，而进展恐惧与较大的疼痛干扰有关。在探索性分析中，我们还发现子宫内膜异位症相关侵入性意象的频率和困扰与进展恐惧和疼痛干扰更大有关，在控制年龄和疼痛强度的情况下。这些结果首次支持了进展恐惧在子宫内膜异位症患者中的重要性，并提出了可能的因果研究路径。版权所有 © 2023 国际疼痛研究学会。

Endometriosis is a chronic gynaecological condition, of which pain is both the most common and most debilitating symptom. As with other forms of pain, there is increasing recognition of the role of psychological processes in bridging the gap between pain and pain impact, and yet these processes are not well understood in endometriosis. The aim of this study was to investigate the relevance of fear of progression, imagery, and interpretation bias in endometriosis, and their contribution to pain interference. A total of 221 participants (mean age = 38 years, SD = 7.8) with endometriosis were recruited from Endometriosis Australia. This cross-sectional study included relevant demographics and endometriosis characteristics; questionnaires to measure fear of progression, imagery, interpretation bias, and pain; and the word association task to measure interpretation bias. Participants reported high scores on the Fear of Progression Questionnaire (M = 38/60), higher than that has been found in cancer. Controlling for age and pain intensity, we found that imagery, interpretation bias, and their interaction were associated with increased fear of progression and that fear of progression was associated with greater pain-related interference. In exploratory analysis, we also found that the frequency and distress of endometriosis-related intrusive imagery were associated with greater fear of progression and pain interference, after controlling for age and pain intensity. These findings provide the first support of the importance of fear of progression in people with endometriosis and suggest possible pathways for causal investigation.Copyright © 2023 International Association for the Study of Pain.