在现代社会，无机纳米颗粒因其在各个领域的无限应用受到了深刻的关注。其中，基于钒的纳米颗粒（VNPs）由于其固有的生理和生物学性质以及许多治疗和其他应用而备受瞩目，例如用于癌症等疾病的药物传递系统，环境修复，能量存储，能量转换和光催化等。此外，物理和化学合成的 VNPs 非常灵活，然而，这些合成途径由于高度恶劣的反应条件，使用高毒性和严酷的化学品，给健康和环境带来了担忧，这迫使研究人员开发一种环境友好、更可持续的合成途径。 在这个观点中，为了避免无数的限制，生物方法被用于化学和物理方法之上。本综述重点讨论了各种生物成分在合成中的作用，尤其是作为覆盖剂和还原剂的植物分子和溶剂系统对纳米颗粒合成的影响。此外，还讨论了各种因素对生物合成纳米颗粒的影响。最后，讨论了合成的 VNPs 的潜在应用，主要包括作为抗菌剂的纳米医药学应用，作为超级电容器和光催化剂的能源应用。

In the modern era, inorganic nanoparticles have received profound attention as they possess boundless applications in various fields. Among these, vanadium-based nanoparticles (VNPs) are highly remarkable due to their inherent physiological and biological properties with many therapeutic and other applications, such as drug delivery systems for diseases like cancer, environmental remediation, energy storage, energy conversion, and photocatalysis. Moreover, physically, and chemically synthesized VNPs are very versatile, however, these synthesis routes cause concern to health and the environment due to the highly savage reaction conditions, using highly toxic and harsh chemicals, which compel the researchers to develop an eco-friendly, greener, and sustainable route for synthesis. In this outlook, to avoid the innumerable limitations, a bio approach is used over chemical and physical methods. This present review emphasis on the role of various biological components in the synthesis, especially Phyto-molecules that acts as capping and reducing agent, and solvent system for the nanoparticles synthesis. Furthermore, the influence of various factors on the biogenic synthesized nanoparticles has also been discussed. Finally, potential applications of as-synthesized VNPs, principally as an antimicrobial agent and their role as a nanomedicine, energy applications as a supercapacitor, and photocatalytic agents, have been discussed.