桑葚果通过调节脂质代谢和miR-155和PPARα的表达，在大鼠中修复酒精性肝损伤。
Mulberry fruit repairs alcoholic liver injury by modulating lipid metabolism and the expression of miR-155 and PPARα in rats.
发表日期：2023 Aug 02
作者：
Jingyi Qiao, Hanwei Li, Chen Jinxiang, Yanmei Shi, Ning Li, Pingsheng Zhu, Sisen Zhang, Mingsan Miao
来源：
ANTIOXIDANTS & REDOX SIGNALING
摘要：
随着饮酒量的增加，酒精性肝病（ALD）越来越普遍，并对人类生命构成威胁。本研究发现桑葚提取物（MFE）通过调节肝内脂质生物合成途径和氧化信号通路修复了由酒精引起的肝损伤（ALI）大鼠的肝脏疾病。MFE的给药抑制了肝内脂质积累，并改善了ALI大鼠的肝脏脂肪变性。MFE还通过增加抗氧化酶活性和降低白介素（IL）-1β和肿瘤坏死因子（TNF）-α的含量，增强了抗氧化能力并缓解了炎症反应。此外，MFE在大鼠中调节了miRNA-155和与脂质代谢相关的PPARα蛋白的表达。miR-155和PPARα在肝功能中扮演重要角色。结果表明，MFE对大鼠ALI具有保护肝脏的作用。© 2023年。作者，独家授权给Springer-Verlag GmbH德国公司，作为Springer Nature的一部分。
As alcohol consumption increases, alcoholic liver disease (ALD) has become more popular and is threating our human life. In this study, we found mulberry fruit extract (MFE) repaired alcohol-caused liver diseases by regulating hepatic lipid biosynthesis pathway and oxidative singling in alcoholically liver injured (ALI) rats. MFE administration inhibited hepatic lipid accumulation and improved liver steatosis in ALI rats. MFE also enhanced the antioxidant capacity and alleviated the inflammatory response by increasing the activities of antioxidant enzymes and decreasing the contents of interleukin (IL)-1β and tumor necrosis factor (TNF)-α. Additionally, MFE regulated the expression of miRNA-155 and lipid metabolism-related PPARα protein in rats. Both miR-155 and PPARα play important roles in liver function. The results indicate that MFE has hepatoprotective effects against ALI in rats.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.