研究动态
Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

多囊卵巢综合征(PCOS)及其相关的心血管代谢风险因素的新方法:膳食多酚。

A New Approach to Polycystic Ovary Syndrome and Related Cardio-metabolic Risk Factors: Dietary Polyphenols.

发表日期:2023 Aug 02
作者: Elif Ulug, Aylin Acikgoz Pinar
来源: DIABETES & METABOLISM

摘要:

多囊卵巢综合征(PCOS)是一种常见的内分泌疾病,其特点是排卵功能障碍、高雄激素血症和多囊卵巢形态,引起多种生殖、代谢、心血管、肿瘤和心理并发症。最近的荟萃分析和系统综述显示,PCOS增加了各种心脏代谢并发症的危险因素,如胰岛素抵抗、2型糖尿病,血脂异常,代谢综合征,高血压和内皮功能障碍。除此之外,有人认为慢性低度炎症和氧化应激是PCOS介导的代谢后果的潜在机制,并可能在患有PCOS的女性中触发心脏代谢风险。现在,有足够的证据表明,各种非营养物质食物成分与炎症和氧化应激一起调节心脏代谢健康。增加膳食多酚的摄入可能减少氧化应激和炎症,从而减轻代谢、内皮和心血管障碍的风险。目前,有越来越多的研究与膳食多酚对PCOS及其相关心脏代谢紊乱的影响有关。然而,膳食多酚对PCOS及其相关心脏代谢后果的可能机制缺乏了解。因此,有必要讨论和评估膳食多酚对PCOS及其相关心脏代谢紊乱的影响及其潜在机制。因此,本综述旨在揭示膳食多酚对PCOS及其相关代谢和心血管风险因素的潜在影响。© 2023. 作者,春天科学商业传媒有限公司旗下斯普林格自然出版集团的独家许可。
Polycystic ovarian syndrome (PCOS) is a common endocrine disease characterized by ovulatory dysfunction, hyperandrogenism, and polycystic ovarian morphology and causing various reproductive, metabolic, cardiovascular, oncological, and psychological complications. Recent meta-analyses and systemic reviews showed that PCOS increases the risk factor for various cardio-metabolic complications like insulin resistance, type II diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, and endothelial dysfunction. In addition to these, it was suggested that chronic low-grade inflammation and oxidative stress are the underlying mechanisms of PCOS-mediated metabolic consequences and might trigger cardio-metabolic risk in women with PCOS. At this point, there is substantial evidence to suggest that various non-nutrient food components modulate cardio-metabolic health together with inflammation and oxidative stress.Increasing the intake of dietary polyphenols might reduce oxidative stress and inflammation and thus alleviate the risk of metabolic, endothelial, and cardiovascular disorders. Nowadays, there are an increasing number of studies related to the effects of dietary polyphenols on PCOS and its accompanying cardio-metabolic disturbances. Currently, there is a cumulative number of studies connected to the effects of dietary polyphenols on PCOS and accompanying cardio-metabolic disturbances. However, there is a lack of knowledge in combining the probable mechanisms of dietary polyphenols on PCOS and related cardio-metabolic consequences. Thus, the effects of dietary polyphenols on PCOS and accompanying cardio-metabolic disturbances need to be discussed and evaluated with underlying mechanisms. Consequently, this review was written to reveal the potential effects of dietary polyphenols on PCOS and related metabolic and cardiovascular risk factors in all their aspects.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.