银屑病是一种慢性炎症性免疫介导和过度增殖的皮肤紊乱，有潜在的遗传因素。银屑病可由角质细胞和T淋巴细胞之间的细胞因子相互作用引起。NEAT是一种涉及免疫调节的长链非编码RNA，在癌症中已有研究。本研究旨在澄清NEAT在银屑病发病机制中的前所未有的作用。该研究对50名健康对照者和50名银屑病患者进行了调查。收集所有参与者的血样进行脂质谱分析。进行了qRT-PCR检测lncRNA NEAT、TNF-α、VEGF基因表达。使用ELISA检测ROS和caspase-3水平。进行了ROC分析以检测lncRNA NEAT基因表达的诊断价值。银屑病患者中脂质代谢失调的发生率更高。与对照组相比，银屑病患者中lncRNA NEAT、TNF-α、VEGF基因表达显著上调（p值<0.001），ROS和caspase-3水平显著增加（p值<0.001）。此外，TNF-α、ROS、NEAT、caspase-3和脂质代谢失调之间存在显著正相关。NEAT的曲线下面积为0.931（95% CI 0.844-0.978，p < 0.001）。脂质代谢失调是银屑病发病机制中的启动信号，会引起慢性炎症和氧化应激状态。这种状态诱导角质细胞增殖和NEAT释放，并随之引起caspase-3的激活以抵消增殖细胞。NEAT可以被视为银屑病的良好诊断生物标志物。© 2023。作者(s)。

Psoriasis is a chronic inflammatory immune-mediated and hyper proliferative skin disorder that has underlying genetic factors. Psoriasis can result from interaction of cytokines between keratinocytes and T-lymphocytes. NEAT is a lncRNA involved in immune modulation and has been previously studied in cancers. This study aims to clarify the unprecedented role of NEAT in psoriasis pathogenesis.The study was conducted on 50 healthy control subjects and 50 psoriasis patients. Blood samples from all participants were collected for analysis of their lipid profile. qRT-PCR was done for lncRNA NEAT, TNF-α, VEGF genes expression. The levels of ROS and caspase-3 were estimated by ELISA. ROC analysis was done to detect the diagnostic value of lncRNA NEAT gene expression.Dyslipidemia is more prevalent among psoriasis patients. A significant up regulation in lncRNA NEAT, TNF-α, VEGF genes expression (p value˂0.001) in psoriasis patients in addition to significant increase in ROS and caspase-3 levels (p value˂0.001) in compare to controls. Additionally, a positive significant correlation between TNF-α, ROS, NEAT, caspase-3 and dyslipidemia. NEAT had an area under the curve (AUC) of 0.931 (95% CI 0.844-0.978, p < 0.001).Dyslipidemia is an initiating signal in psoriasis pathogenesis that creates a state of chronic inflammation and oxidative stress. This state induces keratinocytes proliferation and release of NEAT with subsequent caspase-3 activation to counteract the proliferating cells. NEAT could be considered as a good diagnostic biomarker for psoriasis.© 2023. The Author(s).