良性转移性平滑肌瘤:等待观察策略可行吗?
Benign Metastasizing Leiomyoma: Is "Wait and Watch" Strategy Feasible?
发表日期:2023 Aug 02
作者:
Yixuan Liu, Dong Li, Xueqing Li, Jingnan Wang, Jigang Wang
来源:
HEART & LUNG
摘要:
子宫平滑肌瘤良性转移(BML)是一种罕见的疾病,发生在有子宫平滑肌瘤病史的女性中。本研究旨在调查其临床特征和预后模式。我们从PubMed和Google Scholar索引中收集了385例前期报告,并进行了深入的审查。仔细审查了所有相关的临床参数,包括诊断年龄、临床表现、疾病进程、病史、影像学、分子检测、治疗和预后。进行单变量生存分析,以研究治疗策略对预后的影响。平均诊断年龄为46.2岁。转移最常见于肺部,其次是腹部/盆腔/腹膜后、骨骼、淋巴结和心脏。病史和分子改变是非特异的,病因仍不清楚。由于其不可切除的特性,激素剥夺治疗,包括卵巢切除和激素药物,是减少或延缓肿瘤进展的最有效策略。本研究可能对BML的诊断和管理提供有用的咨询。© 2023. 作者使用独家许可为生殖调查协会.
Benign metastasizing leiomyoma (BML) is a rare disease that affects women with a history of uterine leiomyoma. The aim of this study is to investigate the clinical characteristics and outcome patterns. We collected 385 cases from previous reports indexed in PubMed and Google Scholar and made a thorough review. All relevant clinical parameters were carefully reviewed, including age at diagnosis, clinical presentations, course of disease, medical history, imaging, molecular tests, treatment, and outcomes. Univariate survival analysis was performed to investigate the effects of treatment strategies on outcomes. The mean age at diagnosis was 46.2 years. The most common site for the metastasis was lung, and followed by abdomen/pelvis/retroperitoneum, bone, lymph nodes, and heart. The medical histories and molecular alterations were non-specific, and the pathogenesis was still unclear. Due to its unresectable nature, hormone deprivation treatment, including oophorectomy and hormone drugs, is the most effective strategy to reduce or delay tumor progression. The present study may provide a useful consultation for diagnosing and managing BMLs.© 2023. The Author(s), under exclusive licence to Society for Reproductive Investigation.