纳米纤维是一种具有纳米尺度直径和特定长度直径比的类似金属丝的长材料。纳米纤维具有具有卓越高比表面积和显著孔隙之间的相互连接性的多孔网状结构，可用于化学修饰和药物载荷。金属化纳米纤维是通过静电纺丝掺杂、化学修饰和药物载荷等方法将金属与纳米纤维结合而成的新型材料，它增强了常规纳米纤维的性能特点。由于其独特的物理和化学特性，金属化纳米纤维是物理化学、材料科学和电池制备领域中多样且迅速发展的材料。目前，随着先进制备技术和材料生物相容性水平的提高，金属化纳米纤维的应用正在逐渐扩展到生物医学领域，这是由于其出色的热导性、电导性和独特的金属特性。本综述总结了金属化纳米纤维在生物医学中的应用。建议以安全性和稳定性作为主要材料选择准则，制备用于组织工程、药物输送、肿瘤治疗、伤口愈合和生物传感应用的多功能金属化纳米纤维。最后，总结和讨论了纳米纤维在生物医学应用方面的发展。© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.

Nanofibers are long, wire-like materials with nanoscale diameters and specific length diameter ratios. Nanofibers have porous reticular networks with remarkably high specific surface areas and significant interconnectivity between pores, allowing for the chemical modification and loading of drugs. Metallized nanofibers are novel materials that enhance the performance of attributes of conventional nanofibers by combining metals with nanofibers through electrostatic spinning doping, chemical modification, and loading approaches. Due to their unique physical and chemical properties, metallized nanofibers are diverse, rapidly developed materials in the fields of physical chemistry, materials science, and battery preparation. To date, with improvement in advanced preparation techniques and biocompatibility levels for materials, metallized nanofiber applications are gradually expanding into the biomedical field due to their excellent thermal and electrical conductivities and unique metal properties. In this review, the applications of metallized nanofibers in biomedicine are summarized. It is suggested to prepare metallized multifunctional nanofibers for tissue engineering, drug delivery, tumor treatment, wound healing, and biosensing applications by taking safety and stability as the main material selection guidelines. Finally, the development of nanofibers for biomedical applications is summarized and discussed.© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.