金属基光敏剂作为调节细胞死亡机制的诱导剂。
Metal-Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms.
发表日期：2023 Aug 03
作者：
Yiyi Zhang, Bich-Thuy Doan, Gilles Gasser
来源：
Cell Death & Disease
摘要：
在过去的几十年里，已经发现了多种形式的受调控细胞死亡（RCD），并发现其对癌症治疗有所改善。尽管关于光动力治疗（PDT）诱导RCD的文献综述有几篇，但尚未提供涵盖金属基光敏剂（PSs）作为RCD诱导剂的综合总结。在本综述中，我们系统地总结了金属基PSs诱导不同类型RCD的研究，包括铁死亡、免疫原性细胞死亡（ICD）和火焰病变。解释了每种RCD的特征和机制。在每个部分的结尾，强调了不同金属基PSs诱导相同RCD的已报告共同性，并在综述末尾讨论了金属基PSs诱导新形式RCD的未来展望。考虑到金属基PSs和RCD在癌症治疗中的关键作用，我们希望本综述为金属基PSs作为RCD诱导剂的未来发展提供舞台。
Over the last few decades, various forms of regulated cell death (RCD) have been discovered and were found to improve cancer treatment. Although there are several reviews on RCD induced by photodynamic therapy (PDT), a comprehensive summary covering metal-based photosensitizers (PSs) as RCD inducers has not yet been presented. In this review, we systematically summarize the works on metal-based PSs that induce different types of RCD, including ferroptosis, immunogenic cell death (ICD), and pyroptosis. The characteristics and mechanisms of each RCD are explained. At the end of each section, a summary of the reported commonalities between different metal-based PSs inducing the same RCD is emphasized, and future perspectives on metal-based PSs inducing novel forms of RCD are discussed at the end of the review. Considering the essential roles of metal-based PSs and RCD in cancer therapy, we hope that this review will provide the stage for future advances in metal-based PSs as RCD inducers.