我们旨在评估预糖尿病、糖尿病和糖尿病持续时间与韩国65岁及以上人群的总体和特定部位癌症风险的关联。本研究纳入了1,232,173名接受一般健康筛查计划的65岁及以上受试者。根据糖耐量情况，糖尿病状态分为正常糖耐量、空腹血糖受损、新发糖尿病、糖尿病持续时间<5年和糖尿病持续时间≥5年。使用Cox比例风险模型研究糖尿病状态与癌症风险的关联。总癌症风险随着糖尿病状态恶化而增加，肝脏、胆管和胰腺癌的风险也增加。65-74岁的受试者中肝脏、胆管和胰腺癌的风险显著高于75岁及以上的受试者。糖尿病状态与总体癌症发病率的关系在性别方面存在显著交互作用。在糖尿病患者中，无论糖尿病持续时间如何，男性患者患肝脏癌和肺癌的风险显著高于女性患者。糖尿病状态与老年人癌症风险增加有关。针对糖尿病的老年受试者进行癌症筛查非常重要。版权所有©2023 Elsevier B.V.出版。

We aimed to evaluate the association of prediabetes, diabetes, and diabetes duration with risk of total and site-specific cancer in the Korean population aged 65 years and above.This study included 1,232,173 subjects aged ≥65 years who underwent a general health screening program. Diabetes status was categorized as normal glucose tolerance, impaired fasting glucose, new-onset diabetes, diabetes duration of <5 years, and diabetes duration of ≥5 years. Cox proportional hazards models were used to investigate the association of diabetes status with cancer risk.The risk of total cancer increased as diabetes status worsened, as did the risks of liver, biliary, and pancreatic cancer. Risks of liver, biliary, and pancreatic cancer were significantly higher in subjects aged 65-74 years than in those aged ≥75 years. The relationship of diabetes status with overall cancer incidence was found to significantly interact with sex. Among subjects with diabetes, the risks of liver and lung cancer were significantly higher in men than in women regardless of diabetes duration.Diabetes status is associated with increased risk of cancer in the elderly. There are age and sex differences in the risk of total and site-specific cancers, including liver, biliary, and pancreatic cancer. This study highlights the importance of cancer screening for elderly subjects with diabetes.Copyright © 2023. Published by Elsevier B.V.