口腔疾病中的唾液生物标志物。
Saliva biomarkers in oral disease.
发表日期：2023 Aug 01
作者：
Yuehong Zhou, Zhenqi Liu
来源：
CYTOKINE & GROWTH FACTOR REVIEWS
摘要：
唾液是一种多功能的生物体液，其中含有各种反映生理和病理状态的生物标志物。唾液采集非侵入性，非常适用于需要连续取样的测试。此外，唾液测试的准确性、敏感性和精确性的提高改善了诊断表现以及在口腔疾病过程中新标志物的鉴定。这些口腔疾病包括龋齿、牙周炎、口腔鳞状细胞癌（OSCC）和Sjögren综合征（SS）。许多生长因子、酶、白细胞介素和细胞因子已被鉴定，并成为许多研究的重点。本综述重点介绍了唾液生物标志物成功确定的当前程序，包括与采样、储存和预处理相关的前分析因素以及随后的分析。此外，它还提供了这些唾液生物标志物在常见口腔疾病中的诊断应用概述。版权所有©2023 Elsevier B.V. 保留所有权利。
Saliva is a versatile biofluid that contains a wide variety of biomarkers reflecting both physiologic and pathophysiologic states. Saliva collection is noninvasive and highly applicable for tests requiring serial sampling. Furthermore, advances in test accuracy, sensitivity and precision for saliva has improved diagnostic performance as well as the identification of novel markers especially in oral disease processes. These include dental caries, periodontitis, oral squamous cell carcinoma (OSCC) and Sjögren's syndrome (SS). Numerous growth factors, enzymes, interleukins and cytokines have been identified and are the subject of much research investigation. This review highlights current procedures for successful determination of saliva biomarkers including preanalytical factors associated with sampling, storage and pretreatment as well as subsequent analysis. Moreover, it provides an overview of the diagnostic applications of these salivary biomarkers in common oral diseases.Copyright © 2023 Elsevier B.V. All rights reserved.