本研究的目的是量化使用长轴观察视野（LAFOV；Biograph Vision Quadra）PET / CT系统与短轴观察视野（SAFOV；Biograph Vision）PET / CT系统获取的89Zr免疫PET扫描的SUV之间的任何差异，并评估LAFOV PET扫描持续时间对图像噪声和SUV指标的影响。方法：连续对五例乳腺癌转移患者在SAFOV和LAFOV PET / CT扫描仪上进行扫描。另外四例患者仅使用LAFOV PET / CT进行扫描。两个系统的扫描时间约为30分钟，并在注射37 MBq的89Zr-曲妥珠单抗后的第四天进行采集。 LAFOV列表模式数据经过重新处理以获得采用较短扫描持续时间（15、10、7.5、5和3分钟）获得的图像。在健康组织中放置感兴趣的体积，并对肿瘤进行半自动分割，以比较变异系数，并对SUV指标（SUVmax、SUVpeak和SUVmean）进行Bland-Altman分析。结果：使用30分钟图像，SAFOV与LAFOV PET相比，两个常用的病变SUV指标（SUVmax为16.2% ± 13.4%，SUVpeak为10.1% ± 7.2%）均较高，而健康组织的SUVmean差异极小（0.7% ± 5.8%）。来源于30分钟SAFOV PET的肝脏的变异系数介于3分钟和5分钟LAFOV PET之间。SAFOV和LAFOV之间的SUVmax和SUVpeak差异最小的是3分钟LAFOV PET。结论：由于图像噪声较低，LAFOV 89Zr免疫PET显示出较低的SUVmax和SUVpeak。为了减少图像噪声和SUV指标的偏倚，LAFOV PET扫描持续时间可以缩短。然而，将扫描持续时间从30分钟缩短到10分钟时，SUVpeak的偏倚仅极小。©2023年 核医学与分子影像学协会

The purpose of this study was to quantify any differences between the SUVs of 89Zr immuno-PET scans obtained using a PET/CT system with a long axial field of view (LAFOV; Biograph Vision Quadra) compared to a PET/CT system with a short axial field of view (SAFOV; Biograph Vision) and to evaluate how LAFOV PET scan duration affects image noise and SUV metrics. Methods: Five metastatic breast cancer patients were scanned consecutively on SAFOV and LAFOV PET/CT scanners. Four additional patients were scanned using only LAFOV PET/CT. Scans on both systems lasted approximately 30 min and were acquired 4 d after injection of 37 MBq of 89Zr-trastuzumab. LAFOV list-mode data were reprocessed to obtain images acquired using shorter scan durations (15, 10, 7.5, 5, and 3 min). Volumes of interest were placed in healthy tissues, and tumors were segmented semiautomatically to compare coefficients of variation and to perform Bland-Altman analysis on SUV metrics (SUVmax, SUVpeak, and SUVmean). Results: Using 30-min images, 2 commonly used lesion SUV metrics were higher for SAFOV than for LAFOV PET (SUVmax, 16.2% ± 13.4%, and SUVpeak, 10.1% ± 7.2%), whereas the SUVmean of healthy tissues showed minimal differences (0.7% ± 5.8%). Coefficients of variation in the liver derived from 30-min SAFOV PET were between those of 3- and 5-min LAFOV PET. The smallest SUVmax and SUVpeak differences between SAFOV and LAFOV were found for 3-min LAFOV PET. Conclusion: LAFOV 89Zr immuno-PET showed a lower SUVmax and SUVpeak than SAFOV because of lower image noise. LAFOV PET scan duration may be reduced at the expense of increasing image noise and bias in SUV metrics. Nevertheless, SUVpeak showed only minimal bias when reducing scan duration from 30 to 10 min.© 2023 by the Society of Nuclear Medicine and Molecular Imaging.