评估肝组织活检中的良性肝细胞癌病变。
Evaluating Liver Biopsies with Well-Differentiated Hepatocellular Lesions.
发表日期：2023 Sep
作者：
Sarah E Umetsu, Sanjay Kakar
来源：
MOLECULAR & CELLULAR PROTEOMICS
摘要：
肝脏病变的针核活检可能具有挑战性，特别是在材料有限的情况下。而良性分化的肝细胞性病变的鉴别诊断包括局灶性结节性增生、肝细胞腺瘤和非肝硬化肝脏中的良性分化肝细胞癌（HCC），而在肝硬化肝脏中，鉴别诊断的主要考虑因素是异型结节和良性分化肝细胞癌。本综述的第一部分着重介绍了对鉴别诊断有用的组织化学和免疫组织化学染色以及分子检测方法。第二部分描述了肝细胞腺瘤亚型的特征，并重点探讨了常见的临床病理学情景中的鉴别诊断。版权所有 © 2023 Elsevier Inc. 保留所有权利。
Needle core biopsies of liver lesions can be challenging, particularly in cases with limited material. The differential diagnosis for well-differentiated hepatocellular lesions includes focal nodular hyperplasia, hepatocellular adenoma, and well-differentiated hepatocellular carcinoma (HCC) in noncirrhotic liver, while dysplastic nodules and well-differentiated HCC are the primary considerations in cirrhotic liver. The first part of this review focuses on histochemical and immunohistochemical stains as well as molecular assays that are useful in the differential diagnosis. The second portion describes the features of hepatocellular adenoma subtypes and focuses on the differential diagnoses in commonly encountered clinicopathologic scenarios.Copyright © 2023 Elsevier Inc. All rights reserved.