不那么常见的道路：激活致癌激酶。
The road less traveled: activating an oncogenic kinase.
发表日期：2023 Aug 07
作者：
Madhuri Paul, David A Fruman
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES
摘要：
人类肿瘤中升高的磷脂酰肌醇-3激酶（PI3K）活性引起了广泛的努力，以开发用于肿瘤学应用的化学PI3K抑制剂。在一项创新的新研究中，Gong等人报告了发现了一种高度选择性的PI3Kα亚型激活剂，在神经再生和缺血再灌注损伤（IRI）的心脏保护实验中表现出有希望的活性。版权所有 © 2023 Elsevier Ltd.
Elevated phosphoinositide 3-kinase (PI3K) activity in human tumors has prompted widespread efforts to develop chemical PI3K inhibitors for oncology indications. In an innovative new study, Gong et al. report the discovery of a highly selective activator of the PI3Kα isoform, with promising activity in assays of nerve regrowth and cardioprotection from ischemia-reperfusion injury (IRI).Copyright © 2023. Published by Elsevier Ltd.