组织胺拮抗剂促进癌症免疫监视。
Histamine antagonists promote cancer immunosurveillance.
发表日期：2023
作者：
Peng Liu, Guido Kroemer, Oliver Kepp
来源：
OncoImmunology
摘要：
最近，一个由无限可扩展的树突状细胞和T细胞组成的细胞迷你免疫系统，揭示了组胺受体H1拮抗剂作用于T细胞，促进其增殖并极化向Th1/Tc1表型，从而增强其在免疫化学治疗背景下的抗癌活性。© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.
Recently, a cellular mini-immune system comprising infinitely expandable dendritic cells and T cells led to the discovery that histamine receptor H1 antagonists act on T cells to stimulate their proliferation and polarization toward a Th1/Tc1 phenotype and to increase their anticancer activity in the context of immunochemotherapy.© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.