以氧脱氢酶治疗高氧环境中的抗癌免疫力
Take my breath away: TAM-ing anti-cancer immunity in hypoxic niches.
发表日期：2023 Aug 08
作者：
Aylin Möckl, Lisa Sevenich
来源：
IMMUNITY
摘要：
缺氧是促进胶质母细胞瘤（GBM）肿瘤侵袭性和治疗抵抗性的主要驱动因素。在《免疫学》这期中，Sattiraju等人功能性地将缺氧与GBM中免疫抑制性巨噬细胞和CTL细胞（细胞毒性T淋巴细胞）的囚禁在GBM假乳头状聚集体中导致癌免疫力减弱联系起来。版权所有 © 2023 Elsevier Inc. 保留所有权利。
Hypoxia is a major driver of tumor aggressiveness and therapy resistance in GBM. In this issue of Immunity, Sattiraju et al. functionally link hypoxia with diminished anti-cancer immunity caused by sequestration of immunosuppressive TAMs and CTLs in pseudopalisades in GBM.Copyright © 2023 Elsevier Inc. All rights reserved.