食道鳞状细胞癌患者接受化疗放疗同时进行的血红蛋白、白蛋白、淋巴细胞和血小板评分（HALP）以及改良-古斯塔夫鲁西免疫评分的预测价值。
Predictive values of the hemoglobin, albumin, lymphocyte and platelet score (HALP) and the modified -Gustave Roussy immune score for esophageal squamous cell carcinoma patients undergoing concurrent chemoradiotherapy.
发表日期：2023 Aug 08
作者：
Yujing Shi, Gefenqiang Shen, Yuting Zeng, Mengyang Ju, Xiaojiao Chen, Chenhong He, Liang Liang, Xiaolin Ge, Xinchen Sun, Xiaoke Di
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY
摘要：
HALP评分（hemoglobin, albumin, lymphocyte and platelet score）和Gustave Roussy免疫评分（GRIm-Score）是多种恶性肿瘤的预测标志。然而，HALP评分和GRIm-Score在不能手术切除的食管癌同步化疗放疗中的预测价值尚不明确。我们纳入了2013年至2018年期间在我院接受同步化疗放疗的150例食管鳞癌患者。通过使用受试者工作特征曲线，定义了HALP评分和GRIm-Score的截断值。采用Kaplan-Meier方法分析了存活情况，并用对数秩检验分析差异。采用多变量Cox比例风险模型评估了HALP评分和GRIm-Score对食管鳞癌的预后意义。HALP评分与Zubrod ECOG WHO患者病情、肿瘤位置和临床肿瘤、淋巴结、转移分期显著相关。修正的GRIm（mGRIm）仅与放疗前转移/复发显著相关（χ2 = 6.25）。单变量Cox回归分析显示，较高的mGRIm评分（HR 1.9 95% CI 1.3-2.9）和较低的HALP评分（HR 2.4 95% CI 1.6-3.7）均与较差的总生存率相关。多变量Cox分析发现，较高的mGRIm评分（HR 1.7 95% CI 1.1-2.6）和较低的HALP评分（HR 2 95% CI 1.3-3.2）均为总体生存的独立危险因素。内部验证的量表C-指数为0.66。HALP评分和mGRIm评分均为不能手术切除的食管鳞癌患者的独立预后因素。版权所有©2023 Elsevier B.V. 保留所有权利。
The hemoglobin, albumin, lymphocyte and platelet (HALP) score and the Gustave Roussy immune score (GRIm⁃Score) are prognostic markers in several types of malignant tumors. The prognostic values of HALP score and GRIm⁃Score in concurrent chemoradiotherapy for unresectable esophageal cancer remain unknown.We enrolled 150 esophageal squamous cell carcinoma (ESCC) patients who underwent concurrent chemoradiotherapy in our institution between 2013 and 2018. The cutoff values for HALP, and GRIm⁃Score were defined by using receiver's operating characteristic curves. Survival was analyzed with the Kaplan- Meier method, with differences analyzed with the log-rank test. Multivariate Cox proportional-hazards models were used to evaluate the prognostic significance of HALP and GRIm for ESCC.HALP was significantly associated with the Zubrod ECOG WHO performance status, tumor location, and the clinical tumor, node, metastasis stage. Modified GRIm (mGRIm) was only significantly associated with metastasis / recurrence before radiotherapy (χ2 = 6.25). Univariate Cox regression analysis showed that higher mGRIm (HR 1.9 95%CI 1.3-2.9) and lower HALP (HR 2.4 95%CI 1.6-3.7) were all associated with worse OS. Multivariate COX analysis found that higher mGRIm score (HR 1.7 95%CI 1.1-2.6), and lower HALP score (HR 2 95%CI 1.3-3.2) were both independent risk factors of overall survival. The nomogram c-index in inside validation was 0.66.Both HALP and mGRIm are independent prognostic factors for patients with unresectable ESCC.Copyright © 2023 Elsevier B.V. All rights reserved.