分子标志物和最新的液体活检测试进展：对生物传感器在脑胶质瘤诊断中的应用进行综述。
Molecular Biomarkers and Recent Liquid Biopsy Testing Progress: A Review of the Application of Biosensors for the Diagnosis of Gliomas.
发表日期：2023 Jul 26
作者：
Yuanbin Wu, Xuning Wang, Meng Zhang, Dongdong Wu
来源：
BIOSENSORS & BIOELECTRONICS
摘要：
胶质瘤是最常见的原发性中枢神经系统肿瘤，具有较高的死亡率。对于治疗成功来说，及早准确地诊断胶质瘤至关重要。生物传感器在检测分子生物标志物方面具有重要意义，因为它们使用简单、便携并能进行实时分析。本综述讨论了几种重要的分子生物标志物，以及为胶质瘤诊断而设计的各种生物传感器，如电化学生物传感器和光学生物传感器。我们提出了对现有挑战的观点，并希望这篇综述能促进生物传感器的改进。
Gliomas are the most common primary central nervous system tumors, with a high mortality rate. Early and accurate diagnosis of gliomas is critical for successful treatment. Biosensors are significant in the detection of molecular biomarkers because they are simple to use, portable, and capable of real-time analysis. This review discusses several important molecular biomarkers as well as various biosensors designed for glioma diagnosis, such as electrochemical biosensors and optical biosensors. We present our perspectives on the existing challenges and hope that this review can promote the improvement of biosensors.