咖啡酸苯乙酯（CAPE）属于蜂胶中的酚类物质。已经证实其对头颈癌以及乳腺癌、结直肠癌、肺癌和白血病细胞具有强烈的抗增殖、细胞毒性和促凋亡活性。卵巢癌是最危险的妇科恶性肿瘤之一。其治疗方案包括铂类盐和紫杉醇（PTX）的强化化疗。本研究旨在评估CAPE与紫杉醇联合使用是否增强化疗药物的效果。实验在三个卵巢癌细胞系（OV7、HTB78、和CRL1572）上进行。通过H-E染色、划痕愈合实验、MTT实验和细胞死亡检测ELISAPLUS测试来评估被测试化合物的效果。实验证明极低剂量PTX（10 nM）对所有被测试细胞系都具有细胞毒性作用。此外，所选CAE剂量对被测试的卵巢癌细胞也具有细胞毒性作用。在OV7细胞系中，10 nM PTX和100 µM CAPE同时给药后，细胞毒性效果有所增强。细胞毒性的增加与CAPE剂量（50 µM vs 100 µM）和实验持续时间有关。在其他被测试的细胞系中，PTX的细胞毒性在CAPE给药后没有增加。PTX与CAPE同时给药增加了被测试卵巢癌细胞系中凋亡细胞的百分比。此外，PTX与CAPE同时给药增强了本研究中化疗药物的抗迁移活性。

Caffeic acid phenethyl ester (CAPE) belongs to the phenols found in propolis. It has already shown strong antiproliferative, cytotoxic and pro-apoptotic activities against head and neck cancers and against breast, colorectal, lung and leukemia cancer cells. Ovarian cancer is one of the most dangerous gynecological cancers. Its treatment involves intensive chemotherapy with platinum salts and paclitaxel (PTX). The purpose of this study was to evaluate whether the combined use of CAPE and paclitaxel increases the effectiveness of chemotherapeutic agents. The experiment was performed on three ovarian cancer lines: OV7, HTB78, and CRL1572. The effect of the tested compounds was assessed using H-E staining, a wound-healing test, MTT and the cell death detection ELISAPLUS test. The experiment proved that very low doses of PTX (10 nM) showed a cytotoxic effect against all the cell lines tested. Also, the selected doses of CAPE had a cytotoxic effect on the tested ovarian cancer cells. An increase in the cytotoxic effect was observed in the OV7 line after the simultaneous administration of 10 nM PTX and 100 µM CAPE. The increase in the cytotoxicity was dependent on the CAPE dosage (50 vs. 100 µM) and on the duration of the experiment. In the other cell lines tested, the cytotoxic effect of PTX did not increase after the CAPE administration. The administration of PTX together with CAPE increased the percentage of apoptotic cells in the tested ovarian cancer cell lines. Moreover, the simultaneous administration of PTX and CAPE enhanced the anti-migration activity of the chemotherapeutic used in this study.