高前列腺特异性抗原（PSA）水平可以指示潜在的前列腺问题，并且是前列腺癌的一个预警信号。抗氧化剂对于一般健康男性的PSA数值的影响尚未得到充分研究。本研究旨在评估与PSA水平相关的14种膳食和内源性抗氧化剂在美国男性中的作用。我们使用2003-2010年美国人口基于国家健康与营养调查（NHANES）的数据对7398名男性进行评估。PSA水平被分为三组：正常、边缘和升高水平。我们分别对40-64.9岁和≥65岁的中年和老年人群进行分析。我们进行了加权多项式回归分析以评估与PSA状态相关的抗氧化剂。结果表明，中年男性和老年男性的升高PSA水平的比例分别为0.3%和3.4%（>10 ng/mL）。血清白蛋白水平较高的男性患有升高PSA的风险较低，调整年龄。相较于老年男性，白蛋白对PSA的影响在中年男性中更为显著（升高PSA的OR分别为0.82和0.90，相互作用p = 0.002）。其他抗氧化剂与PSA无关。我们的研究结果支持低血清白蛋白的男性往往具有升高PSA水平，因此可以考虑相关干预措施以减少PSA，维护前列腺健康。

High prostate-specific antigen (PSA) levels can indicate potential prostate problems and are a warning sign of prostate cancer. The impact of antioxidants on the PSA of generally healthy men is understudied. This study aims to evaluate 14 dietary and endogenous antioxidants associated with PSA levels for United States (US) men. We assessed 7398 men using the 2003-2010 US population-based National Health and Nutrition Examination Survey (NHANES). The PSA levels were categorized into three groups: Normal, borderline, and elevated levels. We performed analyses for middle-aged and older groups aged 40-64.9 and ≥65, respectively. The weighted multinomial regressions were performed to evaluate antioxidants associated with the PSA status. For results, 0.3% and 3.4% of middle-aged and older men, respectively, had elevated PSA (>10 ng/mL). Men with a higher serum albumin level had a lower risk of an elevated PSA, adjusting for age. The magnitude of albumin's impact on PSA is larger in middle-aged men than in older men (OR of elevated PSA = 0.82 and 0.90, respectively, interaction p = 0.002). Other antioxidants are not associated with PSA. Our findings support men with low serum albumin tend to have an elevated PSA level, so related interventions can be considered to decrease PSA for maintaining prostate health.