研究动态
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结直肠癌患者接受综合治疗的生存分析:一项回顾性队列研究。

Survival Analysis of Patients with Colorectal Cancer Undergoing Combined Treatment: A Retrospective Cohort Study.

发表日期:2023 Mar
作者: Daem Roshani, Ghobad Moradi, Mohammad Aziz Rasouli
来源: MEDICINE & SCIENCE IN SPORTS & EXERCISE

摘要:

如果结直肠癌(CRC)在早期阶段被诊断出来,患者的生存率将会更高。尽管其他因素可能会影响生存率,但存在的基础健康和治疗设施所提供的治疗类型也非常重要。因此,本研究旨在探索对CRC患者最佳的治疗类型。本研究采用回顾性人群基于队列设计。于2009年3月1日至2014年间,通过基于人群的癌症登记系统收集了库尔德斯坦省335名CRC患者的数据。患者的人口统计学和临床病理数据是通过其医疗记录、病理报告和访问患者居所来获取的。生存率通过Kaplan-Meier曲线、log-rank检验以及单变量和多变量Cox回归来计算。数据使用Stata 14软件进行分析。本研究中,男性在诊断时的平均年龄±标准差为61.7±1.05,女性为60.5±1.12,203名(60.5%)患者为男性。接受手术和化疗治疗的患者死亡率较没有接受任何治疗的患者更低(风险比[HR] = 0.57,95% CI:0.24-0.93)。当CRC患者接受手术和化疗治疗时,他们将表现出更高的生存率。因此,建议对CRC患者同时使用这两种治疗方法。©2023作者;由哈马丹医科大学出版。本文是根据创作共享许可证(https://creativecommons.org/licenses/by/4.0/)发布的开放获取文章,允许在任何媒介上自由使用、分发和复制,前提是原始作品被正确引用。
If colorectal cancer (CRC) is diagnosed in the early stages, the patients will have higher survival rates. Although some other factors might affect the survival rate, the type of treatment available based on existing health and therapeutic facilities is extremely important as well. Accordingly, this study aimed to explore the best type of treatment for CRC patients.This study employed a retrospective population-based cohort design.The data of 335 patients with CRC in Kurdistan province were collected through a population-based cancer registry system from March 1, 2009 to 2014. Demographic and clinical-pathologic data of the patients were gathered through their medical records, pathology reports, and reference to patients' homes. The survival rate was calculated using the Kaplan-Meier curve, log-rank test, and univariate and multivariate Cox regression. The data were analyzed using Stata 14 software.In this study, the mean age±standard deviation at diagnosis was 61.7± 1.05 in men and 60.5± 1.12 in women, respectively, and 203 (60.5%) patients were males. There was less mortality rate among the patients who received both surgical and chemotherapy treatments compared to those who did not receive any treatment (Hazard ratio [HR]=0.57, 95% CI: 0.24-0.93).When CRC patients are treated using both surgical and chemotherapy treatments, they will exhibit a higher survival rate. Therefore, it is suggested to use both treatments for CRC patients.© 2023 The Author(s); Published by Hamadan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.