基因组引导的癌症治疗靶点的发现。
Genome-guided discovery of cancer therapeutic targets.
发表日期：2023 Aug 10
作者：
Prathyusha Konda, Simon Garinet, Eliezer M Van Allen, Srinivas R Viswanathan
来源：
Cell Reports
摘要：
精准肿瘤学的成功，旨在根据分子状态将适当的治疗方案匹配给适当的患者，并且其前提是拥有一个稳健的分子靶点管线，以便开发出相应的治疗方法。近期基因组学和功能遗传学的进展使得无偏倚地能够大规模地发现新的分子靶点。我们在本文总结了将肿瘤的基因组和功能遗传学景观整合起来以建立下一代肿瘤靶点的前景和挑战。
版权©2023作者。由爱思唯尔公司出版。保留所有权利。
The success of precision oncology-which aims to match the right therapies to the right patients based on molecular status-is predicated on a robust pipeline of molecular targets against which therapies can be developed. Recent advances in genomics and functional genetics have enabled the unbiased discovery of novel molecular targets at scale. We summarize the promise and challenges in integrating genomic and functional genetic landscapes of cancer to establish the next generation of cancer targets.Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.