卵巢癌(OC)是一种常见的影响女性的肿瘤性疾病。细胞外囊泡(EVs)是由各种细胞在生理和病理状态下分泌的纳米级膜囊泡。EVs与卵巢癌肿瘤微环境(TME)之间的深入相互作用是至关重要的。在本综述中，我们探讨了EVs在促进癌细胞和TME之间进行细胞间通讯方面的关键作用，强调了EVs作为卵巢癌有希望的诊断标志物和创新治疗靶点的潜力。全面分析了EVs与TME成分之间的特定机制，包括通过携带基质金属蛋白酶(MMPs)和EV介导的抑制血管生成来调节肿瘤生长。此外，我们还讨论了以EVs靶向卵巢癌TME的潜在临床应用，包括建立新的治疗策略和鉴定早期检测和预后的新生物标志物。最后，本综述确定了治疗干预的新策略，例如利用EVs作为药物传递载体和靶向特定EV介导信号通路。总之，本文提供了有关EVs在卵巢癌中的作用的宝贵见解，并强调在癌症生物学领域理解细胞间通讯的重要性。版权所有© 2023. Elsevier B.V.出版。

Ovarian cancer (OC) is a prevalent neoplastic condition affecting women. Extracellular vesicles (EVs), nano-sized membrane vesicles, are secreted by various cells in both physiological and pathological states. The profound interplay between EVs and the tumor microenvironment (TME) in ovarian cancer is crucial. In this review, we explores the pivotal role of EVs in facilitating intercellular communication between cancer cells and the TME, emphasizing the potential of EVs as promising diagnostic markers and innovative therapeutic targets for ovarian cancer. The comprehensive analysis outlines the specific mechanisms by which EVs engage in communication with the constituents of the TME, including the modulation of tumor growth through EVs carrying matrix metalloproteinases (MMPs) and EV-mediated inhibition of angiogenesis, among other factors. Additionally, the we discuss the potential clinical applications of EVs that target the TME in ovarian cancer, encompassing the establishment of novel treatment strategies and the identification of novel biomarkers for early detection and prognosis. Finally, this review identifies novel strategies for therapeutic interventions, such as utilizing EVs as carriers for drug delivery and targeting specific EV-mediated signaling pathways. In summary, this manuscript offers valuable insights into the role of EVs in ovarian cancer and highlights the significance of comprehending intercellular communication in the realm of cancer biology.Copyright © 2023. Published by Elsevier B.V.