对年轻患者进行综合治疗是必要的，其中包括辅助生殖技术用于晚期边缘性卵巢肿瘤的治疗。然而，长期随访病例的具体细节尚未报告。在本报道中，一位19岁的患者出现了ⅡＩＩＩＣ期浆液型边缘性肿瘤。该患者接受了五次保留生育能力的手术。肿瘤对三线化疗均未作出反应。在使用了leuprorelin荷尔蒙治疗之后，观察到了血清学和放射学的反应，随后进行了第四次手术。在计划的第五次手术中对附件进行完全切除之前，进行了受精卵的冷冻保存。当无病存活期超过先前的期限时，即在36岁时，我们提出了胚胎移植的建议；然而，该患者拒绝了生育治疗。该患者患有类风湿性关节炎，生育不是优先考虑的问题。该患者在最后一次手术后生活了7年，并且在最初就诊后20年内没有任何疾病的证据。© 2023年日本妇产科学会。

Multimodal treatment, including assisted reproductive technology, is necessary in young patients with advanced borderline ovarian tumors. However, the details of long-term follow-up cases have not been reported. In this report, a 19-year-old patient presented with a stage IIIC serous borderline tumor. The patient underwent five fertility-sparing surgeries. The tumor did not respond to any of the three lines of chemotherapy administered. Serological and radiological responses were observed following hormonal treatment with leuprorelin, followed by a fourth surgery. Before the planned fifth surgery for complete resection of both adnexa, cryopreservation of the fertilized eggs was performed. At age 36, when the disease-free interval exceeded the previous one, we proposed embryo transfer; however, she declined fertility treatment. The patient had developed rheumatoid arthritis and childbirth not a priority. The patient had lived without any evidence of disease for 7 years following the last surgery and 20 years after the initial visit.© 2023 Japan Society of Obstetrics and Gynecology.