PLC-β广泛分布于真核细胞中，是磷脂酰肌醇信号转导通路的关键酶。其四个亚型（PLC-β1、PLC-β2、PLC-β3、PLC-β4）调控的细胞功能对维持生物体稳态起着重要作用。PLC-β及其相关信号通过影响细胞的生长、分化和转移，可以促进或抑制癌症的发生和发展，而针对PLC-β1-PI3K-AKT，PLC-β2/CD133，CXCR2-NHERF1-PLC-β3，Gαq-PLC-β4-PKC-MAPK等的靶向干预，可以为恶性肿瘤的精准预防和治疗提供新策略。本文从增殖与分化、侵袭与转移、血管生成和保护措施四个方面综述了PLC-β在各种肿瘤细胞中的作用机制。版权所有©2023吴某某、苏某某、王某某、刘某某、徐某某。

PLC-β is widely distributed in eukaryotic cells and is the key enzyme in phosphatidylinositol signal transduction pathway. The cellular functions regulated by its four subtypes (PLC-β1, PLC-β2, PLC-β3, PLC-β4) play an important role in maintaining homeostasis of organism. PLC-β and its related signals can promote or inhibit the occurrence and development of cancer by affecting the growth, differentiation and metastasis of cells, while targeted intervention of PLC-β1-PI3K-AKT, PLC-β2/CD133, CXCR2-NHERF1-PLC-β3, Gαq-PLC-β4-PKC-MAPK and so on can provide new strategies for the precise prevention and treatment of malignant tumors. This paper reviews the mechanism of PLC-β in various tumor cells from four aspects: proliferation and differentiation, invasion and metastasis, angiogenesis and protective measures.Copyright © 2023 Wu, Su, Wang, Liu and Xu.