苯并噁唑是杂环芳烃的一种富有创造力和重要的成员，它将合成有机化学与医学、药学和工业领域相连接。它是一个双环平面分子，并且是研究者们最喜欢的结构单元，因为它已广泛用作药物发现中不同机理方法的起始材料。该结构单元显示了广泛的底物范围和官能团化可能性，提供了多种生物活性，如抗微生物、抗真菌、抗癌、抗氧化、抗炎等。近年来，苯并噁唑的合成反应途径有了大幅增长。本文介绍了自2018年以来苯并噁唑衍生物合成策略的最新进展。使用2-氨基苯酚与醛、酮、酸、醇、异硫氰酸酯、邻酯和炔酮等在不同反应条件和催化剂下，如纳米催化剂、金属催化剂和离子液体催化剂等，通过各类有机合成方法对苯并噁唑进行高效合成的各种优化合成方法进行了总结。本期刊由英国皇家化学学会出版。

Benzoxazole is a resourceful and important member of the heteroarenes that connects synthetic organic chemistry to medicinal, pharmaceutical, and industrial areas. It is a bicyclic planar molecule and is the most favorable moiety for researchers because it has been extensively used as a starting material for different mechanistic approaches in drug discovery. The motif exhibits a high possibility of broad substrate scope and functionalization to offer several biological activities like anti-microbial, anti-fungal, anti-cancer, anti-oxidant, anti-inflammatory effects, and so on. There has been a large upsurge in the synthesis of benzoxazole via different pathways. The present article presents recent advances in synthetic strategies for benzoxazole derivatives since 2018. A variety of well-organized synthetic methodologies for benzoxazole using 2-aminophenol with aldehydes, ketones, acids, alcohols, isothiocyanates, ortho-esters, and alkynones under different reaction conditions and catalysts, viz. nanocatalysts, metal catalysts, and ionic liquid catalysts, with other miscellaneous techniques has been summarized.This journal is © The Royal Society of Chemistry.