老年急性髓系白血病（AML）患者中，与静脉血栓栓塞（VTE）相关的风险因素尚不清楚。本研究旨在确定VTE与已知风险因素的关联，并评估VTE对白人、黑人和亚洲人老年AML患者的死亡率影响。使用融合的SEER-Medicare数据库（2000-2015年）的65岁及以上的AML患者进行研究。使用多元逻辑回归分析VTE与已知风险因素的关联，并利用Cox比例风险回归评估VTE与白人、黑人和亚洲人患者的死亡率关联。在接受至少65岁的21,403名AML患者中，18,731名白人患者中有10.6％的人被诊断为VTE，1362名黑人患者中有13.4％的人被诊断为VTE，1310名亚洲人患者中有5.6%的人被诊断为VTE。总体而言，黑人患者与白人患者的VTE风险相似，但亚洲人患者的VTE风险较低。白人患者的VTE风险因素包括75岁以下的年龄、女性性别、化疗和合并存在的高血压、贫血、慢性肾脏和肺疾病、高血脂、心力衰竭和肥胖症等医疗状况。在黑人患者中，高血脂和心力衰竭与VTE相关，在亚洲人患者中，75岁以下的年龄、女性性别、化疗和高血压、心肌梗死与VTE相关。无论是白人、黑人还是亚洲人，中心静脉导管植入都是VTE的预测因素。我们的研究确定了白人、黑人和亚洲人老年AML患者中与种族相关的VTE风险因素。版权所有©2023 Wolters Kluwer Health, Inc. 保留所有权利。

Risk factors for venous thromboembolism (VTE) in elderly patients with acute myeloid leukemia (AML) are not known by race. The aim of this study was to determine the association of VTE with known risk factors and the impact of VTE on mortality in elderly white, black and Asian patients with AML. The merged SEER-Medicare database (2000-2015) was used for patients aged at least 65 years diagnosed with AML. Multivariable logistic regression was used to examine the association of VTE with known risk factors and Cox proportional hazards regression was used to evaluate the association of VTE with mortality in white, black and Asian patients. Among 21 403 AML patients aged at least 65years, VTE was diagnosed in 10.6% of 18 731 white patients, 13.4% of 1362 black and 5.6% of 1310 Asian patients. Overall, the adjusted risk of VTE in black patients was similar to white patients, but Asian patients had a lower risk of VTE. Risk factors for VTE in white patients were age less than 75 years, female sex, chemotherapy and comorbid medical conditions, including hypertension, anemia, chronic kidney and lung disease, hyperlipidemia, heart failure and obesity. In black patients, hyperlipidemia, and heart failure and in Asian patients, age less than 75 years, female sex, chemotherapy and hypertension and myocardial infarction were associated with VTE. Central venous catheter placement was a predictor of VTE in all three races. Our study identified risk factors for VTE by race in elderly white, black and Asian AML patients.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.