肺癌是一种复杂且异质性的疾病，其特征是肺细胞异常生长和增殖。它是全球癌症相关死亡的主要原因，约占所有癌症死亡人数的18%。近年来，靶向治疗已成为治疗肺癌的一种有前景的方法，其涉及使用选择性靶向特定分子或信号通路的药物，这些分子或信号通路对肿瘤细胞的生长和存活至关重要。液液相分离（LLPS）是一种基本的生物过程，发生在细胞中，使蛋白质和其他生物分子分离成不同的液相。LLPS对于各种细胞功能至关重要，包括膜无器官的形成、基因表达的调控，以及对压力和其他刺激的响应。最近的研究表明，LLPS在肺癌的靶向治疗中起着关键作用，包括肿瘤基因蛋白的隔离和基于LLPS的药物传递系统的开发。了解LLPS在这些过程中的机制可能揭示治疗耐药性的肺癌细胞的新疗法策略。© 2023. Society of Chinese Bioscientists in America (SCBA).

Lung cancer is a complex and heterogeneous disease characterized by abnormal growth and proliferation of lung cells. It is the leading cause of cancer-related deaths worldwide, accounting for approximately 18% of all cancer deaths. In recent years, targeted therapy has emerged as a promising approach to treat lung cancer, which involves the use of drugs that selectively target specific molecules or signaling pathways that are critical for the growth and survival of cancer cells. Liquid-liquid phase separation (LLPS) is a fundamental biological process that occurs when proteins and other biomolecules separate into distinct liquid phases in cells. LLPS is essential for various cellular functions, including the formation of membraneless organelles, the regulation of gene expression, and the response to stress and other stimuli. Recent studies have shown that LLPS plays a crucial role in targeted therapy of lung cancer, including the sequestration of oncogenic proteins and the development of LLPS-based drug delivery systems. Understanding the mechanisms of LLPS in these processes could provide insights into new therapeutic strategies to overcome drug resistance in lung cancer cells.© 2023. Society of Chinese Bioscientists in America (SCBA).