造血干细胞为我们提供了终身的血细胞供应。因此，它们的正常功能对生命来说是极其重要的，而它们的功能异常可能导致感染和恶性疾病。这些细胞具有特定的代谢需求，以实现它们终生的功能和产血能力。带着罗马诗人尤文纳尔的“健康的心灵在健康的身体中”这句话，我们对我们日常饮食与我们的血液质量之间的联系感到好奇，并希望通过特定的饮食调整来改善我们的造血干细胞功能并预防疾病。如今，膳食补充剂是一个不断扩大的市场，充满了提供更好健康的潜力和承诺。然而，许多这些补充剂与人体生理的联系尚不清楚。一些研究团体已开始通过研究特定营养物质对造血过程的代谢调控来阐明这一点。除了与膳食补充剂的联系外，这些研究还显著提高了我们对基本造血干细胞生物学的理解。在此，我们总结了关于特定维生素和氨基酸对正常造血和造血干细胞功能的影响的最新知识，这些物质可能被考虑为膳食补充剂。我们提出，提高我们对营养与血液生理之间联系的理解，最终可以推动健康保健政策、流程和标准的优化。版权所有 © 2023年。由Elsevier Inc.发表。

Hematopoietic stem cells provide us with a life-long supply of blood cells. Hence, their proper function is absolutely essential for life, and their dysfunction can lead to infectious and malignant diseases. These cells have specific metabolic requirements to enable their life-long function and blood-producing capacity. With the words of the Roman poet Juvenal "a healthy mind in a healthy body" in mind, it is intriguing to understand the connection between our daily diet to the quality of our blood, with the hope that through specific dietary adjustments we can improve our hematopoietic stem cell function and prevent disease. Nowadays, dietary supplements are an expanding market, filled with potential and promises for better health. However, the link of many of those supplements to human physiology is obscure. Several groups have begun to shed light on this by investigating the metabolic regulation of hematopoiesis by specific nutrients. Beyond the link to dietary supplementation, these studies have also significantly improved our understanding of basic hematopoietic stem cell biology. Herein we summarize recent knowledge on the effect of specific vitamins and amino acids, which might be considered as dietary supplements, on normal hematopoiesis and hematopoietic stem cell function. We propose that improving our understanding on the link between nutrition in general and blood physiology can ultimately lead to optimization of health-care policies, protocols and standard of care.Copyright © 2023. Published by Elsevier Inc.