尽管早期头颈肿瘤具有良好的预后率，但大约一半的肿瘤在晚期阶段发现，并具有不良预后。化疗、放疗和手术的联合治疗是头颈癌（HNC）患者的治疗选择。然而，顺铂作为一线药物在HNC患者的治疗中起着重要作用，但大量患者观察到对顺铂的耐药性。因此，鉴定与顺铂耐药性相关的分子机制有助于减少副作用，并提供更好的治疗管理。作为转录后调节因子，微小RNA（miRNA）在抗药性中起着重要作用。因此，在本综述中，我们研究了miRNA在头颈肿瘤对顺铂反应中的作用。已有研究报道了miRNA通过调控WNT、NOTCH、PI3K/AKT、TGF-β和NF-kB等信号通路以及凋亡、自噬和EMT过程来发挥其在顺铂反应中的作用。本综述为建议在HNC患者中预测顺铂反应的非创伤性miRNA基因组标记开辟了道路。因此，这种诊断性miRNA基因组标记能够减少顺铂的副作用，并在高效的治疗管理后提高这些患者的临床结果。© 2023. BioMed Central Ltd., 一部分在斯普林格自然出版集团。

Although, there is a high rate of good prognosis in early stage head and neck tumors, about half of these tumors are detected in advanced stages with poor prognosis. A combination of chemotherapy, radiotherapy, and surgery is the treatment option in head and neck cancer (HNC) patients. Although, cisplatin (CDDP) as the first-line drug has a significant role in the treatment of HNC patients, CDDP resistance can be observed in a large number of these patients. Therefore, identification of the molecular mechanisms involved in CDDP resistance can help to reduce the side effects and also provides a better therapeutic management. MicroRNAs (miRNAs) as the post-transcriptional regulators play an important role in drug resistance. Therefore, in the present review we investigated the role of miRNAs in CDDP response of head and neck tumors. It has been reported that the miRNAs exerted their roles in CDDP response by regulation of signaling pathways such as WNT, NOTCH, PI3K/AKT, TGF-β, and NF-kB as well as apoptosis, autophagy, and EMT process. The present review paves the way to suggest a non-invasive miRNA based panel marker for the prediction of CDDP response among HNC patients. Therefore, such diagnostic miRNA based panel marker reduces the CDDP side effects and improves the clinical outcomes of these patients following an efficient therapeutic management.© 2023. BioMed Central Ltd., part of Springer Nature.