白血病是全球儿童最常见的癌症形式。由于疾病的进展、治疗的有害影响和长时间的住院过程，白血病儿童经历了各种问题。为了增加他们的福祉和缓解问题，这些儿童需要持续支持。家长和专业人士可以使用的一个解决方案是游戏治疗。本系统综述的目的是确定游戏治疗在白血病儿童身上的类型和有效性。我们在PubMed、Scopus、ScienceDirect和ProQuest数据库中进行了搜索。此外，我们还在Google Scholar、Google Web和灰色文献中进行了手工搜索。纳入标准包括：1）对白血病儿童实施游戏治疗的研究，2）英文或印度尼西亚语的全文文章，时间范围为2000年1月至2021年12月，并更新至2023年7月，3）采用准实验性或随机对照试验（RCT）设计的干预研究。从1099篇文章中，选出了16个研究。发现了几种形式的游戏治疗，包括假装游戏、音乐游戏、艺术游戏和沙盘游戏。在这个系统综述中的16项研究中，有15项显示出对心理问题，特别是焦虑、绝望、压力和身体问题（疲劳和疼痛）的益处。游戏治疗有效地缓解了白血病儿童的某些身体和心理问题。护士可以将游戏治疗作为白血病儿童的干预措施。此外，建议进行一项类似的研究，采用相同的研究策略，研究具有相同设计的研究。PROSPERO CRD42022318549.版权所有©2023 Elsevier Inc.。保留所有权利。

Leukemia is the most common form of childhood cancer worldwide. Children living with leukemia experience various problems because of the disease's progression, harmful effects of treatment, and prolonged hospitalization process. To increase their well-being and alleviate their problems, these children require ongoing support. One solution that both parents and professionals can use is play therapy. This systematic review aimed to identify the type and effectiveness of play therapy in children living with leukemia.We searched PubMed, Scopus, ScienceDirect, and ProQuest databases. Additionally, we performed manual searches on Google Scholar, Google Web, and grey literature. Inclusion criteria comprised: 1) Studies that implemented play therapy on leukemia children, 2) Full-text articles available in English or Indonesian languages from January 2000 to December 2021 and updated until July 2023, and 3) Intervention studies employing quasi-experimental or randomized controlled trial (RCT) designs.From 1099 articles, 16 studies were selected. Several forms of play therapy were found, including pretend, music, art, and sand play therapy.Of the sixteen studies in this systematic review, fifteen demonstrated beneficial effects on psychological issues, particularly anxiety, despair, stress, and physical problems (fatigue and pain).Play therapy effectively alleviates some physical and psychosocial problems in children living with leukemia.Nurses can utilize play therapy as an intervention for children living with leukemia. Additionally, comparative research is recommended with a similar research strategy concerning studies with the same design.PROSPERO CRD42022318549.Copyright © 2023 Elsevier Inc. All rights reserved.