在Savana Manager平台上使用大数据方法评估甲状腺功能减退患者不同癌症类型的发生率。本研究采用观察性、回顾性研究设计，使用马德里Puerta de Hierro Majadahonda大学医院的电子病历（EMR）数据。利用人工智能技术提取EMR中的信息，并使用Savana Manager v3.0软件进行分析。搜索使用词条“甲状腺功能减退”以及相应的肿瘤术语。在总人口数为506,749的样本中，有23,570例（4.7%）被诊断为甲状腺功能减退。与非甲状腺功能减退人群相比，患有该疾病的患者患癌症的发生率明显较高（OR为2.09，95%置信区间[CI]为2.01-2.17）。这种较高的发生率在女性（OR为1.99，95% CI为1.90-2.08）和男性（OR为2.83，95% CI为2.63-3.05）中均存在。然而，在60岁以上的甲状腺功能减退患者中，并未观察到较高的癌症发生率（OR为0.97，95% CI为0.92-1.02）。尽管大多数单独研究的肿瘤在甲状腺功能减退人群中的发生率较高，但我们观察到60岁以上的甲状腺功能减退患者前列腺癌、肺癌、结直肠癌和肝癌的发生率显著降低。这家医院的队列数据表明，甲状腺功能减退的诊断与癌症之间存在显著关联。然而，对于60岁以上的甲状腺功能减退患者，这种关联并不明显。版权所有 © 2022 SEEN and SED. Elsevier España, S.L.U.发表所有权利保留。

To evaluate the frequency of different types of cancer in patients diagnosed with hypothyroidism using big data methodology on the Savana Manager platform.An observational, retrospective study was carried out using electronic medical record (EMR) data from the Hospital Universitario Puerta de Hierro Majadahonda (Madrid). Information from the EMRs was extracted using artificial intelligence techniques and analysed using the Savana Manager v3.0 software. Searches were performed using the term "hypothyroidism" and the terms corresponding to the tumours analysed.Of a total population of 506,749 patients, 23,570 (4.7%) were diagnosed with hypothyroidism. Patients with this diagnosis had a significantly higher frequency of cancer than that found in non-hypothyroid subjects (OR 2.09, 95% confidence interval [CI] 2.01-2.17). This higher frequency was found both in women (OR 1.99, 95% CI 1.90-2.08) and in men (OR 2.83, 95% CI 2.63-3.05). However, this higher frequency of cancer was not observed in hypothyroid patients older than 60 years (OR 0.97, 95% CI 0.92-1.02). Although the frequency of most of the neoplasms studied individually was higher in the population with hypothyroidism, we observed that hypothyroid patients over 60 years of age had a significant decrease in the frequency of prostate, lung, colorectal, and liver cancer.Data from this hospital cohort suggest that there is a significant association between the diagnosis of hypothyroidism and cancer. However, this association is less evident in hypothyroid patients older than 60 years.Copyright © 2022 SEEN and SED. Published by Elsevier España, S.L.U. All rights reserved.