生物体已经进化出各种策略，将硫和硒纳入生物活性天然产物中。这些含有硫和硒的化合物对其产生者具有重要和多样化的生物学功能，其中许多对抗传染病和癌症的药物是不可或缺的。我们回顾了近年来在一些含硫/硒天然产物合成中的一些进展，重点关注C-S / C-Se键的形成或裂解。我们强调介绍了催化这些转化的非常规酶，描述了它们的研究机制，并讨论了理解这些酶如何有助于发现和合成含有硫或硒的新型天然产物。Copyright © 2023 Elsevier Ltd. All rights reserved.

Living organisms have evolved various strategies to incorporate sulfur and selenium into bioactive natural products. These chalcogen-containing compounds serve important and diverse biological functions for their producers and many of them are essential medicines against infectious diseases and cancer. We review recent advances in the biosynthesis of some sulfur/selenium-containing natural products with a focus on the formation or cleavage of C-S/C-Se bonds. We highlight unusual enzymes that catalyze these transformations, describe their proposed mechanisms, and discuss how understanding these enzymes may facilitate the discovery and synthesis of novel natural products containing sulfur or selenium.Copyright © 2023 Elsevier Ltd. All rights reserved.