引言 骨巨细胞瘤（GCT）主要侵犯手臂和腿部的长骨，并且很少涉及手部和脚部的小骨。由于其非特异性的体征和症状，很难根据临床发现进行诊断；因此，需要组织病理学证据来确认诊断。 方法 我们的研究包括16例组织病理学骨病变呈阳性的患者。在完整评估其病历记录后，进行了所需的放射学评估。采用Campanacci分期法评估病变的进展情况。手术后记录了肌肉骨骼肿瘤学会（MSTS）评分。所有患者平均随访时间为2.8年，直到他们失去随访。 结果 当前研究结果显示，62.5%的患者出现在二十多岁，并且81.25%的患者处于相当晚期阶段。手和脚各涉及一例。患者被采用以下任一方法进行治疗：扩大刮除并进行骨移植或填充物注入，广泛切除或结节切除。邻位辅助治疗中使用了酚。我们的两名患者（6.25%）在随访期间经历了刮除并进行骨移植后复发，其中一例随后接受了广泛切除，另一例接受了截肢。 结论 无疑应该积极对待骨巨细胞瘤，目标是保持肢体功能，同时将复发风险降至最低。相比之下，手部的GCT更具侵袭性，应相应处理。 版权所有 © 2023 Patel等。

Introduction Giant cell tumor (GCT) or bony tumor mainly involving long bones of arms and legs is very rarely associated with the small bones of hands and feet. Due to its nonspecific signs and symptoms, it is not easy to diagnose based on clinical findings; therefore, histopathological evidence is required to confirm it. Method A total of 16 patients with positive histopathological bone lesions enriched with giant cells were included in our study. After a complete evaluation of their case records, the required radiological assessment was carried out. Campanacci's method of staging was used to evaluate the advancement of lesions. The Musculoskeletal Tumour Society (MSTS) score was recorded postoperatively. All the patients were followed up for a mean duration of 2.8 years until they were lost to follow-up. Result The result of the current study shows that 62.5% of our patients presented in their twenties and 81.25% of patients came at a reasonably advanced stage. Hand and foot were involved in 1:1 cases. Patients were treated by one of the following options: extended curettage with bone graft or cement, wide excision, or en bloc resection. Phenol, a neoadjuvant, was used in all patients. Two of our patients (6.25%) who underwent curettage with bone graft showed up with recurrence during follow-up - one was then treated with wide excision and the other with amputation. Conclusion Giant cell tumors should undoubtedly be aggressively approached with the goal of preserving limb function while reducing recurrence risk to as minimal as possible. GCT of hand is more aggressive comparatively and should be treated accordingly.Copyright © 2023, Patel et al.