建造具有优越电化学活性的新型二维多孔碳纳米片是一个巨大的挑战。在这里，通过顺序的室温自组装和高温碳化方法，轻松获得了石墨烯/ZIF-8纳米三明治衍生的N，P共掺杂多孔碳纳米片（N,P共掺杂PCN）。相对于广泛使用的物理剥离的石墨烯纳米片（GN）和石墨烯/ZIF-8衍生的N掺杂多孔碳纳米片（N掺杂PCN），N,P共掺杂PCN表现出更大的活性表面，更快的电子传输能力和更强的物理吸附能力，这可以归因于杂原子N和P的双掺杂效应。因此，N,P共掺杂PCN在肿瘤标志物（8-羟基-2'-去氧鸟苷）、止痛退热药（对乙酰氨基酚）和有机农药（苯骈）的氧化信号增强方面表现出卓越性能。此外，对于8-羟基-2'-去氧鸟苷、对乙酰氨基酚和苯骈，检测限低至1.58nM、7.50nM和2.10nM，灵敏度分别为270.00μA·μM-1·cm-2、757.14μA·μM-1·cm-2和272.86μA·μM-1·cm-2。基于此，开发了一种新颖、高灵敏度的电化学传感平台。我们相信，报道的具有独特结构和组成的二维N,P共掺杂PCN对于碳基电化学传感器的发展具有重要价值。版权所有 © 2023 Elsevier B.V.。保留所有权利。

Construction of novel two-dimensional porous carbon nanosheets with superior electrochemical activity is of great challenge. Here, graphene/ZIF-8 nano-sandwiches derived N, P-codoped porous carbon nanosheets (N, P-codoped PCN) was easily obtained by sequential room temperature self-assembly and high-temperature carbonization method. Relative to the widely used physically exfoliated graphene nanosheets (GN) and graphene/ZIF-8 derived N-doped porous carbon nanosheets (N-doped PCN), N, P-codoped PCN displayed larger active surface, faster electron transport ability and stronger physical adsorption ability, which can be ascribed to the dual doping effect of heteroatoms N and P. As a result, N, P-codoped PCN exhibited remarkable oxidation signal enhancement for tumor marker (8-hydroxy-2'-deoxyguanosine), analgesic and antipyretic drug (acetaminophen) and organic pesticide (benomyl). Besides, the limits of detection were measured as low as 1.58 nM, 7.50 nM and 2.10 nM with sensitivity of 270.00 μA μM-1 cm-2, 757.14 μA μM-1 cm-2 and 272.86 μA μM-1 cm-2 for 8-hydroxy-2'-deoxyguanosine, acetaminophen and benomyl, respectively. Basing on this, a novel and highly sensitive electrochemical sensing platform was developed. It is believed that the reported two-dimensional N, P-codoped PCN with unique structure and composition is highly valuable for the development of carbon-based electrochemical sensors.Copyright © 2023 Elsevier B.V. All rights reserved.