儿童癌症之后的监测:心脏肌肉病的风险增加的幸存者是否定期进行随访?
Surveillance after childhood cancer: are survivors with an increased risk for cardiomyopathy regularly followed-up?
发表日期:2023 Aug 21
作者:
Nicolas Bougas, Rodrigue S Allodji, Chiraz Fayech, Nadia Haddy, Imene Mansouri, Neige Journy, Charlotte Demoor, Julie Allard, Eric Thebault, Aurore Surun, Hélène Pacquement, Claire Pluchart, Pierre-Yves Bondiau, Delphine Berchery, Anne Laprie, Marjorie Boussac, Angela Jackson, Vincent Souchard, Giao Vu-Bezin, Christelle Dufour, Dominique Valteau-Couanet, Florent de Vathaire, Brice Fresneau, Agnès Dumas
来源:
BRITISH JOURNAL OF CANCER
摘要:
我们旨在研究高患心肌病风险的长期儿童癌症幸存者(CC)在心脏筛查方面的依从性。该研究包括来自法国儿童癌症幸存者研究的976名高患心肌病风险的5年期CC。采用多变量逻辑回归模型研究了依从推荐的监测的决定因素。使用Cox回归模型估计了长期随访(LTFU)访视的参与与心脏超声检查的完成之间的关联。在参与者中,有32%在之前5年内进行了心脏超声检查。男性(校正相对风险[aRR] 0.71,95% CI 0.58-0.86)、年龄为36-49岁的幸存者(aRR 0.79,95% CI 0.64-0.98)、神经母细胞瘤幸存者(aRR 0.53,95% CI 0.30-0.91)和中枢神经系统肿瘤幸存者(aRR 0.43,95% CI 0.21-0.89)更不可能依从推荐的监测。对于之前未依从推荐的患者,参加LTFU访视与完成心脏超声检查相关(HR 8.20,95% CI 5.64-11.93)。大多数高患心肌病风险的长期幸存者未能遵守推荐的监测要求。参加LTFU访视明显提高了心脏超声检查的完成率,但需要进一步开展干预措施以覆盖更多的幸存者。© 2023年。作者,授予Springer Nature Limited独家许可。
We aimed to study adherence to cardiac screening in long-term childhood cancer survivors (CCS) at high risk of cardiomyopathy.This study involved 976 5-year CCS at high risk for cardiomyopathy from the French Childhood Cancer Survivor Study. Determinants of adherence to recommended surveillance were studied using multivariable logistic regression models. Association of attendance to a long-term follow-up (LTFU) visit with completion of an echocardiogram was estimated using a Cox regression model.Among participants, 32% had an echocardiogram within the 5 previous years. Males (adjusted RR [aRR] 0.71, 95% CI 0.58-0.86), survivors aged 36-49 (aRR 0.79, 95% CI 0.64-0.98), Neuroblastoma (aRR 0.53, 95% CI 0.30-0.91) and CNS tumour survivors (aRR 0.43, 95% CI 0.21-0.89) were less likely to adhere to recommended surveillance. Attendance to an LTFU visit was associated with completion of an echocardiogram in patients who were not previously adherent to recommendations (HR 8.20, 95% CI 5.64-11.93).The majority of long-term survivors at high risk of cardiomyopathy did not adhere to the recommended surveillance. Attendance to an LTFU visit greatly enhanced the completion of echocardiograms, but further interventions need to be developed to reach more survivors.© 2023. The Author(s), under exclusive licence to Springer Nature Limited.