HELLP综合征和转移性乳腺癌:一位产后患者罕见的散在性血管内凝血和难治性血小板减少的重叠现象。
Hemolysis, Elevated Liver Enzymes and Low Platelets (HELLP) Syndrome and Metastatic Breast Cancer: A Rare Overlap in a Postpartum Patient With Disseminated Intravascular Coagulation and Refractory Thrombocytopenia.
发表日期:2023 Jul
作者:
Elvis Mesa, Dylan Miles, Nayle Araguez-Ancares, Damian Casadesus
来源:
Cell Death & Disease
摘要:
一名中年女性因初级保健医生的转诊而来到三级护理医院,以评估超声发现的左侧乳房肿块是否恶性。患者同时怀孕27周,孕育着单绒唯一的双胎。在接诊过程中,发现她有严重高血压和与HELLP(溶血、肝酶升高、血小板减少)综合征有关的实验室异常,于是进行了剖腹产。她在分娩后对左侧乳房肿块进行了活检,后被诊断为浸润性导管癌并发脊柱转移和大量转移性肺结节。她住院期间并发了右下肢深静脉血栓形成、急性硬脑膜下血肿和弥漫性血管内凝血,出现顽固性血小板减少,最终导致死亡。版权所有 © 2023年,Mesa等人。
A middle-aged female arrived at a tertiary care hospital after a referral from her primary care physician to evaluate a left breast mass found on ultrasound concerning malignancy. The patient was also 27 weeks gestational with monochorionic diamniotic twins. During triage, she was found to have severe hypertension and lab abnormalities concerning HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome and underwent cesarean delivery of the infants. She had a biopsy of the left breast mass post-delivery, later diagnosed as invasive ductal cell carcinoma with spinal metastasis and numerous metastatic pulmonary nodules. Her hospital stay was complicated by a right lower extremity deep vein thrombosis, acute subdural hematoma, and disseminated intravascular coagulation with refractory thrombocytopenia resulting in her death.Copyright © 2023, Mesa et al.